Response to antiseizure medications in neonates with acute symptomatic seizures

被引：34

作者：

Glass, Hannah C. ^{[1
,2
,3
]}

Soul, Janet S. ^{[4
]}

Chu, Catherine J. ^{[5
]}

Massey, Shavonne L. ^{[6
,7
,8
]}

Wusthoff, Courtney J. ^{[9
,10
]}

Chang, Taeun ^{[11
]}

Cilio, Maria Roberta ^{[1
,2
]}

Bonifacio, Sonia L. ^{[12
]}

Abend, Nicholas S. ^{[6
,7
,8
,13
,14
]}

Thomas, Cameron ^{[15
]}

Lemmon, Monica ^{[16
]}

McCulloch, Charles E. ^{[3
]}

Shellhaas, Renee A. ^{[17
]}

机构：

[1] Univ Calif San Francisco, Benioff Childrens Hosp, Dept Neurol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Benioff Childrens Hosp, Dept Pediat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[4] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

[6] Univ Penn, Childrens Hosp Philadelphia, Dept Neurol, Philadelphia, PA 19104 USA

[7] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[8] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[9] Stanford Univ, Dept Neurol, Palo Alto, CA 94304 USA

[10] Stanford Univ, Dept Pediat, Palo Alto, CA 94304 USA

[11] George Washington Univ, Sch Med, Childrens Natl Hlth Syst, Dept Neurol, Washington, DC USA

[12] Stanford Univ, Dept Pediat, Div Neonatal & Dev Med, Palo Alto, CA 94304 USA

[13] Univ Penn, Childrens Hosp Philadelphia, Dept Anesthesia, Perelman Sch Med, Philadelphia, PA 19104 USA

[14] Univ Penn, Childrens Hosp Philadelphia, Dept Crit Care Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[15] Univ Cincinnati, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Div Neurol, Cincinnati, OH USA

[16] Duke Univ, Dept Pediat, Sch Med, Div Pediat Neurol & Dev Med, Durham, NC 27706 USA

[17] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA

来源：

EPILEPSIA | 2019年 / 60卷 / 03期

关键词：

AED; antiepileptic drug; electroencephalogram; epilepsy; hypoxic-ischemic encephalopathy; neonatal encephalopathy; neonatal seizures; neurocritical care; seizure; INTRAVENOUS LEVETIRACETAM; PHARMACOKINETICS;

D O I：

10.1111/epi.14671

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.

引用

页码：E20 / E24

页数：5

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