Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia

被引：59

作者：

Crans-Vargas, HN

Landaw, EM

Bhatia, S

Sandusky, G

Moore, TB

Sakamoto, KM

机构：

[1] Univ Calif Los Angeles, Mattel Childrens Hosp, Dept Pediat, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Gwynne Hazen Cherry Mem Labs, Div Hematol Oncol, Dept Pediat, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Pathol, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Med, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90024 USA

[6] City Hope Natl Med Ctr, Dept Pediat, Div Hematol Oncol, Duarte, CA 91010 USA

[7] Eli Lilly & Co, Res Labs, Indianapolis, IN 46285 USA

来源：

BLOOD | 2002年 / 99卷 / 07期

关键词：

D O I：

10.1182/blood.V99.7.2617

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclic adenosine monophosphate response-element binding protein (CREB) is a nuclear protein that regulates expression of genes that control cell proliferation, differentiation, and survival. To analyze CREB expression in leukemia cells, we conducted Western blot analysis of bone marrow cells obtained from patients with acute lymphoblastic leukemia:, patients with acute myeloid leukemia, and patients without active, leukemia. CREB was expressed at a higher frequency in bone marrow cells from patients with acute lymphoid or myeloid leukemia than in patients with leukemia remission or without leukemia. Our results indicate that CREB expression could be a useful marker for leukemia In patients with acute disease and suggest a role for CREB in leukemogenesis. (C) 2002 by The American Society of Hematology.

引用

页码：2617 / 2619

页数：3

共 15 条

[1] Transcription factors and translocations in lymphoid and myeloid leukemia [J].