Synthesis and Biological Evaluation of New Bis-Indolyl (3-O-Benzyl-1,2-O-Isopropylidenexylopentadialdose-α-D-Glucofuranose)

被引：0

作者：

Shankar, M. ^{[1
]}

Balasubramaniam, A. ^{[2
]}

Gowrishankar, N. L. ^{[3
]}

Mahendran, S. ^{[4
]}

机构：

[1] Swami Vivekanandha Inst Pharmaceut Sci, Dept Pharmaceut Chem, Vangapally 508286, AP, India

[2] JKK Munirajah Med Res Fdn Coll Pharm, Dept Pharmaceut Chem, Komarapalayam 638183, TN, India

[3] Swami Vivekanandha Inst Pharmaceut Sci, Dept Pharmacognosy, Vangapally 508286, AP, India

[4] JSS Coll Pharm, Dept Pharmaceut Chem, Ootacamund 643001, TN, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 47卷 / 10期

关键词：

3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose; antibacterial activity; anti-inflammatory activity;

D O I：

10.1007/s11094-014-1001-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose has emerged as structurally new antibacterial and anti-inflammatory agent. Therefore, various substituted bis-indolyl- (3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose glucofuranose) derivatives were synthesized by addition of substituted xylopentadialdose with various substituted indoles. The structures of the synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR, and mass spectroscopy techniques. All the synthesised compounds showed maximum zone of inhibition againt both Gram-positive and Gram-negative organisms. In the anti-inflammatory activity test, three compounds (1, 3 and 5) produced significant activity in a dose-dependent manner.

引用

页码：544 / 548

页数：5