Melatonin Effects on Hard Tissues: Bone and Tooth

被引：66
作者：
Liu, Jie [1 ,2 ]
Huang, Fang [1 ,2 ]
He, Hong-Wen [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510055, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Stomatol, Guangzhou 510080, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 05期
基金：
中国国家自然科学基金;
关键词：
melatonin; bone remolding; osteoporosis; tooth development; osseointegration; MESENCHYMAL STEM-CELLS; QUALITY-OF-LIFE; OSTEOBLAST DIFFERENTIATION; EXPERIMENTAL OSTEOPOROSIS; IN-VITRO; FRACTURE; METABOLISM; RECEPTORS; BIOLOGY; HEALTH;
D O I：
10.3390/ijms140510063
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
] Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an important role in many physiological processes including circadian entrainment, blood pressure regulation, seasonal reproduction, ovarian physiology, immune function, etc. Recently, the investigation and applications of melatonin in the hard tissues bone and tooth have received great attention. Melatonin has been investigated relative to bone remolding, osteoporosis, osseointegration of dental implants and dentine formation. In the present review, we discuss the large body of published evidence and review data of melatonin effects on hard tissues, specifically, bone and tooth.
引用
收藏
页码：10063 / 10074
页数：12
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