Primary apocrine adenocarcinoma of the lacrimal sac: an extremely rare variant of lacrimal sac neoplasm

被引:4
作者
Alam, Md Shahid [1 ]
Chandran, Vazhipokkil Anju [2 ]
KrishnaKumar, Subramanian [3 ]
机构
[1] Aditya Birla Sankara Nethralaya, Orbit Oculoplasty Reconstruct & Aesthet Serv, Kolkata, India
[2] Med Res Fdn, Orbit Oculoplasty Reconstruct & Aesthet Serv, Sankara Nethralaya, Chennai, Tamil Nadu, India
[3] Sankara Nethralaya, Larson & Turbo Dept Ocular Pathol, Vis Res Fdn, Chennai, Tamil Nadu, India
来源
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY | 2022年 / 41卷 / 02期
关键词
Apocrine adenocarcinoma; atypical; lacrimal sac;
D O I
10.1080/01676830.2020.1825752
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
A 52-year-old male presented with right eye prominence of 1-year duration. Right eye examination revealed proptosis and limitation of extraocular movements. Magnetic resonance imaging (MRI) of the orbit showed soft tissue mass in the inferomedial orbit with medial rectus involvement and involving lacrimal sac. The patient underwent an incisional biopsy. Histopathology confirmed a diagnosis of primary orbital adenocarcinoma. Positron emission tomography computed tomography (PET CT) did not show the involvement of any other organ. Right orbital exenteration was done for disease control. On histopathology the mass was found to be arising from the lacrimal sac and was reported as apocrine adenocarcinoma. The diagnosis was further confirmed by immunohistochemistry with the tumor staining positive for gross cystic disease fluid protein 15 (GCDFP 15). The patient received adjuvant radiotherapy and is alive without any recurrence at 1 year of follow up. Apocrine adenocarcinomas are rare malignant skin adnexal tumors. Involvement of lacrimal sac is extremely rare with only one case reported in the literature till date. Immunohistochemistry utilizing GCDFP 15 stain can confirm the diagnosis.
引用
收藏
页码:241 / 244
页数:4
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