Rumphellclovanes C-E, new clovane-type sesquiterpenoids from the gorgonian coral Rumphella antipathies

被引：22

作者：

Chung, Hsu-Ming ^{[1
,2
,3
]}

Su, Jui-Hsin ^{[1
,2
,3
,4
,5
,6
]}

Hwang, Tsong-Long ^{[7
]}

Li, Jan-Jung ^{[3
]}

Chen, Jih-Jung ^{[8
,9
]}

Chen, Yung-Husan ^{[3
]}

Chang, Yu-Chia ^{[3
,10
,11
]}

Su, Yin-Di ^{[1
,2
,3
]}

Chen, Yu-Hsin ^{[3
,4
,5
,6
]}

Fang, Lee-Shing ^{[12
]}

Sheu, Jyh-Horng ^{[1
,2
,10
,11
]}

Wang, Wei-Hsien ^{[1
,2
,3
]}

Sung, Ping-Jyun ^{[1
,2
,3
,4
,5
,6
,13
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[4] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[5] Natl Dong Hwa Univ, Dept Life Sci, Pingtung 944, Taiwan

[6] Natl Dong Hwa Univ, Inst Biotechnol, Pingtung 944, Taiwan

[7] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[8] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[9] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[10] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan

[11] Acad Sinica, Kaohsiung 804, Taiwan

[12] Cheng Shiu Univ, Dept Sport Hlth & Leisure, Kaohsiung 833, Taiwan

[13] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

TETRAHEDRON | 2013年 / 69卷 / 13期

关键词：

Clovane; Rumphellclovane; Rumphella; Superoxide anion; Elastase; SINDORA-SUMATRANA MIQ; SUPEROXIDE ANION; ELASTASE RELEASE; HUMAN NEUTROPHILS; CARYOPHYLLANE; CONSTITUENTS;

D O I：

10.1016/j.tet.2013.01.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new clovane-related sesquiterpenoids, rumphellclovanes C-E (1-3), and a new natural clovane, clovan-2,9-dione (4), were isolated from a gorgonian coral Rumphella antipathies. The structures of clovanes 1-4 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Rumphelldovane C (1) was proven to be the first clovane-type sesquiterpenoid containing an epsilon-lactone moiety. A plausible biosynthetic pathway between clovanes 1 and 2 was proposed. Clovane 4 displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2740 / 2744

页数：5

共 27 条

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