Characterisation of the ecotoxicity of hospital effluents: A review

被引:169
作者
Orias, Frederic [1 ]
Perrodin, Yves [1 ]
机构
[1] Univ Lyon, ENTPE, CNRS, UMR LEHNA 5023, F-69518 Vaulx En Velin, France
关键词
Hospital wastewater; Ecotoxicity; Chemical pollutants; Pharmaceuticals; PNEC; WASTE-WATER TREATMENT; ENVIRONMENTAL RISK-ASSESSMENT; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; PERSONAL CARE PRODUCTS; SURFACE WATERS; HUMAN PHARMACEUTICALS; AQUATIC ORGANISMS; TREATMENT PLANTS; PRIORITY PHARMACEUTICALS;
D O I
10.1016/j.scitotenv.2013.02.064
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The multiple activities that take place in hospitals (surgery, drug treatments, radiology, cleaning of premises and linen, chemical and biological analysis laboratories, etc.), are a major source of pollutant emissions into the environment (disinfectants, detergents, drug residues, etc.). Most of these pollutants can be found in hospital effluents (HWW), then in urban sewer networks and WWTP (weakly adapted for their treatment) and finally in aquatic environments. In view to evaluating the impact of these pollutants on aquatic ecosystems, it is necessary to characterise their ecotoxicity. Several reviews have focused on the quantitative and qualitative characterisation of pollutants present in HWW. However, none have focused specifically on the characterisation of their experimental ecotoxicity. We have evaluated this according to two complementary approaches: (i) a "substance" approach based on the identification of the experimental data in the literature for different substances found in hospital effluents, and on the calculation of their PNEC (Predicted Non Effect Concentration), (ii) a "matrix" approach for which we have synthesised ecotoxicity data obtained from the hospital effluents directly. This work first highlights the diversity of the substances present within hospital effluents, and the very high ecotoxicity of some of them (minimum PNEC observed close to 0,01 pg/L). We also observed that the consumption of drugs in hospitals was a predominant factor chosen by authors to prioritise the compounds to be sought. Other criteria such as biodegradability, excretion rate and the bioaccumulability of pollutants are considered, though more rarely. Studies of the ecotoxicity of the particulate phase of effluents must also be taken into account. It is also necessary to monitor the effluents of each of the specialised departments of the hospital studied. These steps is necessary to define realistic environmental management policies for hospitals (replacement of toxic products by less pollutant ones, etc.). (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:250 / 276
页数:27
相关论文
共 94 条
[51]   Impact of wastewaters and hospital effluents on the occurrence of controlled substances in surface waters [J].
Lin, Angela Yu-Chen ;
Wang, Xiao-Huan ;
Lin, Cheng-Fang .
CHEMOSPHERE, 2010, 81 (05) :562-570
[52]   Occurrence of pharmaceuticals in Taiwan's surface waters: Impact of waste streams from hospitals and pharmaceutical production facilities [J].
Lin, Angela Yu-Chen ;
Tsai, Yu-Ting .
SCIENCE OF THE TOTAL ENVIRONMENT, 2009, 407 (12) :3793-3802
[53]   Pharmaceutical contamination in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan [J].
Lin, Angela Yu-Chen ;
Yu, Tsung-Hsien ;
Lin, Cheng-Fang .
CHEMOSPHERE, 2008, 74 (01) :131-141
[54]   Determination of antibiotic substances in hospital sewage water using solid phase extraction and liquid chromatography/mass spectrometry and group analogue internal standards [J].
Lindberg, R ;
Jarnheimer, PÅ ;
Olsen, B ;
Johansson, M ;
Tysklind, M .
CHEMOSPHERE, 2004, 57 (10) :1479-1488
[55]   Impacts of florfenicol on marine diatom Skeletonema costatum through photosynthesis inhibition and oxidative damages [J].
Liu, Wenhua ;
Ming, Yao ;
Huang, Zhongwen ;
Li, Ping .
PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2012, 60 :165-170
[56]   Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry [J].
Liu, Xianjun ;
Zhang, Jing ;
Yin, Jie ;
Duan, Hejun ;
Wu, Yongning ;
Shao, Bing .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 396 (08) :2977-2985
[57]   Analytical method for the determination of the aminoglycoside gentamicin in hospital wastewater via liquid chromatography electrospray-tandem mass spectrometry [J].
Löffler, D ;
Ternes, TA .
JOURNAL OF CHROMATOGRAPHY A, 2003, 1000 (1-2) :583-588
[58]   Pharmaceuticals in the environment: Good practice in predicting acute ecotoxicological effects [J].
Madden, Judith C. ;
Enoch, Steven J. ;
Hewitt, Mark ;
Cronin, Mark T. D. .
TOXICOLOGY LETTERS, 2009, 185 (02) :85-101
[59]   Fate of 5-fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimination by activated sludge and treatment in a membrane-bio-reactor system [J].
Mahnik, S. N. ;
Lenz, K. ;
Weissenbacher, N. ;
Mader, R. M. ;
Fuerhacker, M. .
CHEMOSPHERE, 2007, 66 (01) :30-37
[60]   Determination of 5-fluorouracil in hospital effluents [J].
Mahnik, SN ;
Rizovski, B ;
Fuerhacker, M ;
Mader, RM .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2004, 380 (01) :31-35