Cancer Epigenetics, Tumor Immunity, and Immunotherapy

被引：256

作者：

Cao, Jian ^{[1
,2
]}

Yan, Qin ^{[3
]}

机构：

[1] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08901 USA

[2] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Med, New Brunswick, NJ 08901 USA

[3] Yale Sch Med, Dept Pathol, Yale Canc Ctr, Yale Stem Cell Ctr, New Haven, CT 06520 USA

来源：

TRENDS IN CANCER | 2020年 / 6卷 / 07期

基金：

美国国家卫生研究院;

关键词：

INHIBITORY RECEPTOR PD-1; CD8(+) T-CELLS; MHC CLASS-I; DNA METHYLATION; PROMOTER METHYLATION; EXPRESSION; SURVIVAL; PROCAINAMIDE; ACTIVATION; RESISTANCE;

D O I：

10.1016/j.trecan.2020.02.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epigenetic mechanisms, including DNA methylation, histone post-translational modifications, and chromatin structure regulation, are critical for the interactions between tumor and immune cells. Emerging evidence shows that tumors commonly hijack various epigenetic mechanisms to escape immune restriction. As a result, the pharmaceutical modulation of epigenetic regulators, including 'writers', 'readers', 'erasers', and 'remodelers', is able to normalize the impaired immunosurveillance and/or trigger antitumor immune responses. Thus, epigenetic targeting agents are attractive immunomodulatory drugs and will have major impacts on immuno-oncology. Here, we discuss epigenetic regulators of the cancer-immunity cycle and current advances in developing epigenetic therapies to boost anticancer immune responses, either alone or in combination with current immunotherapies.

引用

页码：580 / 592

页数：13

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