Signal transducer and activator of transcription (STAT) 3 has been described as a "master regulator" of signaling pathways involved in the transition from low-grade glioma (LGG) to high-grade glioma (HGG). Although STAT3 is overexpressed in HGGs, it remains unclear whether its overexpression is sufficient to induce or promote the malignant progression of glioma. To characterize the effect of STAT3 expression on tumor progression in vivo, we expressed the STAT3 gene in glioneuronal progenitor cells in mice. STAT3 was expressed alone or concurrently with platelet-derived growth factor B (PDGFB), a well-described initiator of LGG. STAT3 alone was insufficient to induce tumor formation; however, coexpression of STAT3 with PDGFB in mice resulted in a significantly higher incidence of HGGs than PDGFB alone. The median symptomatic tumor latency in mice coexpressing STAT3 and PDGFB was significantly shorter, and mice that developed symptomatic tumors demonstrated significantly higher expression of phosphorylated STAT3 intratumorally. In HGGs, expression of STAT3 was associated with suppression of apoptosis and an increase in tumor cell proliferation. HGGs induced by STAT3 and PDGFB also displayed frequent foci of necrosis and microvascular proliferation. The expression of CD31 (a marker of endothelial proliferation) was significantly higher in tumors induced by coexpression of STAT3 and PDGFB. When mice injected with PDGFB and STAT3 were treated with a STAT3 inhibitor, median survival increased and the incidence of HGG and CD31 expression decreased significantly. These results demonstrate that STAT3 promotes the malignant progression of glioma. Inhibiting STAT3 expression mitigates tumor progression and improves survival, validating it as a therapeutic target.
机构:
Shandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R ChinaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Gao, Peng
Niu, Na
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Dept Pediat, Shandong Prov Hosp, Jinan, Shandong, Peoples R ChinaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Niu, Na
Wei, Tianshu
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R ChinaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Wei, Tianshu
Tozawa, Hideto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Res Ctr Adv Sci & Technol, Isotope Sci Ctr, Meguro Ku, Tokyo, JapanShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Tozawa, Hideto
Chen, Xiaocui
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R ChinaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Chen, Xiaocui
Zhang, Caiqing
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Resp Med, Jinan, Shandong, Peoples R ChinaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Zhang, Caiqing
Zhang, Jiandong
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Radiat Oncol, Jinan, Shandong, Peoples R ChinaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Zhang, Jiandong
Wada, Youichiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Res Ctr Adv Sci & Technol, Isotope Sci Ctr, Meguro Ku, Tokyo, JapanShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Wada, Youichiro
Kapron, Carolyn M.
论文数: 0引用数: 0
h-index: 0
机构:
Trent Univ, Dept Biol, Peterborough, ON, CanadaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
Kapron, Carolyn M.
Liu, Ju
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R ChinaShandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, Jinan, Shandong, Peoples R China
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
He, Jinlong
Bao, Qiankun
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Bao, Qiankun
Zhang, Yan
论文数: 0引用数: 0
h-index: 0
机构:Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Zhang, Yan
Liu, Mingming
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Liu, Mingming
Lv, Huizhen
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Lv, Huizhen
Liu, Yajin
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Liu, Yajin
论文数: 引用数:
h-index:
机构:
Yao, Liu
Li, Bochuan
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Li, Bochuan
Zhang, Chenghu
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Zhang, Chenghu
He, Shuang
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Modern Chinese Med, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
He, Shuang
Zhai, Guijin
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Zhai, Guijin
Zhu, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Modern Chinese Med, Tianjin, Peoples R China
Tianjin Key Lab Metab Dis, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Zhu, Yan
Liu, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Key Lab Network Genet, Collaborat Innovat Ctr Cardiovasc Disorders, Inst Genet & Dev Biol, Beijing, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Liu, Xin
Zhang, Kai
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Zhang, Kai
Wang, Xiu-Jie
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Key Lab Network Genet, Collaborat Innovat Ctr Cardiovasc Disorders, Inst Genet & Dev Biol, Beijing, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Wang, Xiu-Jie
Zou, Ming-Hui
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Ctr Mol & Translat Med, Atlanta, GA 30303 USATianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Zou, Ming-Hui
Zhu, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R China
Tianjin Med Univ, Eye Hosp, Eye Inst, Coll Optometry & Ophthalmol, Tianjin, Peoples R ChinaTianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin, Peoples R China
机构:
Heze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
Wu, Lei
Gao, Lanying
论文数: 0引用数: 0
h-index: 0
机构:
Heze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
Gao, Lanying
Kong, Decai
论文数: 0引用数: 0
h-index: 0
机构:
Heze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
Kong, Decai
Xue, Hongfeng
论文数: 0引用数: 0
h-index: 0
机构:
Heze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, Dept Gen Surg, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
机构:
Kyoto Univ, Dept Surg, Grad Sch Med, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Kasai, Yosuke
Toriguchi, Kan
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Univ Calif San Francisco, Dept Surg, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USAKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Toriguchi, Kan
Hatano, Etsuro
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Hyogo Coll Med, Dept Surg, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Hatano, Etsuro
Nishi, Kiyoto
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Nishi, Kiyoto
Ohno, Mikiko
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Ohno, Mikiko
论文数: 引用数:
h-index:
机构:
Yoh, Tomoaki
Fukuyama, Keita
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Surg, Grad Sch Med, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Fukuyama, Keita
Nishio, Takahiro
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Surg, Grad Sch Med, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Nishio, Takahiro
论文数: 引用数:
h-index:
机构:
Okuno, Masayuki
Iwaisako, Keiko
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Target Therapy & Oncol, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Iwaisako, Keiko
论文数: 引用数:
h-index:
机构:
Seo, Satoru
论文数: 引用数:
h-index:
机构:
Taura, Kojiro
Kurokawa, Masato
论文数: 0引用数: 0
h-index: 0
机构:
Sanyo Chem Ind, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Kurokawa, Masato
Kunichika, Makoto
论文数: 0引用数: 0
h-index: 0
机构:
Sanyo Chem Ind, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Kunichika, Makoto
Uemoto, Shinji
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Surg, Grad Sch Med, Kyoto, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan
Uemoto, Shinji
Nishi, Eiichiro
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan
Shiga Univ Med Sci, Dept Pharmacol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, JapanKyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan