Lymph node vascular-stromal growth and function as a potential target for controlling immunity

被引：15
作者：
Benahmed, Fairouz [1 ]
Ely, Scott [2 ]
Lu, Theresa T. [1 ,3 ]
机构：
[1] Hosp Special Surg, Autoimmun & Inflammat Program, New York, NY 10021 USA
[2] Cornell Univ, Weill Med Coll, Div Hematopathol, Dept Pathol, New York, NY 10065 USA
[3] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10065 USA
来源：
CLINICAL IMMUNOLOGY | 2012年 / 144卷 / 02期
关键词：
Lymph node; Blood vessels; Lymphatic; High endothelial venules; Stromal; Lupus; FIBROBLASTIC RETICULAR CELLS; ADULT-ONSET; T-CELLS; BLOCKADE INCREASES; ANTIGEN; SECONDARY; DISEASE; LYMPHANGIOGENESIS; LYMPHADENOPATHY; FOLLICLES;
D O I：
10.1016/j.clim.2012.05.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lymphadenopathy occurs in many autoimmune and inflammatory diseases, and vascular proliferation is a common feature in the enlarged lymph nodes. The lymph node vasculature plays critical roles in delivering immune cells as well as oxygen and micronutrients, and therefore represents a potential target for therapeutic manipulation of immunity. In this review, we discuss recent insights made in understanding the growth and function of the vascular and associated stromal compartment in immune-stimulated lymph nodes and the potential utility of altering this process in autoimmune diseases. (C) 2012 Elsevier Inc. All rights reserved.
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收藏
页码：109 / 116
页数：8
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