Protective effects of salidroside from Rhodiola rosea on LPS-induced acute lung injury in mice

被引：69

作者：

Guan, Shuang ^{[1
,2
]}

Xiong, Ying ^{[1
]}

Song, Bocui ^{[1
]}

Song, Yu ^{[1
]}

Wang, Dacheng ^{[1
]}

Chu, Xiao ^{[1
]}

Chen, Na ^{[1
]}

Huo, Meixia ^{[1
]}

Deng, Xuming ^{[1
]}

Lu, Jing ^{[1
,2
]}

机构：

[1] Jilin Univ, Dept Vet Pharmacol, Coll Anim Sci & Vet Med, Changchun 130062, Jilin, Peoples R China

[2] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Jilin, Peoples R China

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2012年 / 34卷 / 04期

关键词：

Salidroside; protective; LPS; ALI; INFLAMMATORY RESPONSE; L; EXTRACT; IN-VITRO; LIPOPOLYSACCHARIDE; ENDOTOXIN; STRESS; RATS;

D O I：

10.3109/08923973.2011.650175

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Salidroside is a major component extracted from Rhodiola rosea. In this study, we investigated protective effects of salidroside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. In the mouse model, we found that pretreatment with a single 120 mg/kg dose of salidroside prior to the administration of intratracheal LPS induced a significant decrease in the W/D ratio and mouse myeloperoxidase activity of lung, reduction protein concentration, the number of total cells, neutrophils and macrophages in the bronchoalveolar lavage fluid. In addition, salidroside also inhibited the production of several inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-6 (IL-6) and IL-1 beta,and the NF-kappa B DNA-binding activation after LPS challenge. These results indicated that salidroside possess a protective effect on LPS-induced ALI in mice.

引用

页码：667 / 672

页数：6

共 28 条

[1] AN INVIVO HAMSTER BIOASSAY TO ASSESS THE TOXICITY OF PARTICULATES FOR THE LUNGS [J].

BECK, BD ;

BRAIN, JD ;

BOHANNON, DE .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 66 (01) :9-29

[2]

BRIGHAM KL, 1986, AM REV RESPIR DIS, V133, P913

[3] Preventive Effects of Valnemulin on Lipopolysaccharide-Induced Acute Lung Injury in Mice [J].

Chen, Zhibao ;

Zhang, Xuemei ;

Chu, Xiao ;

Zhang, Xiaozhe ;

Song, Keji ;

Jiang, Youshuai ;

Yu, Lu ;

Deng, Xuming .

INFLAMMATION, 2010, 33 (05) :306-314

[4] Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats [J].

Chu, Pei-Yi ;

Chien, Se-Ping ;

Hsu, Dur-Zong ;

Liu, Ming-Yie .

FOOD AND CHEMICAL TOXICOLOGY, 2010, 48 (07) :1821-1826

[5] Adjuvant effects of salidroside from Rhodiola rosea L. on the immune responses to ovalbumin in mice [J].

Guan, Shuang ;

He, Jiakang ;

Guo, Weixiao ;

Wei, Jingyuan ;

Lu, Jing ;

Deng, Xuming .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2011, 33 (04) :738-743

[6] Attenuation of Long-Term Rhodiola rosea Supplementation on Exhaustive Swimming-Evoked Oxidative Stress in the Rat [J].

Huang, Shih-Chuang ;

Lee, Fang-Tsai ;

Kuo, Tz-Yin ;

Yang, Joan-Hwa ;

Chien, Chiang-Ting .

CHINESE JOURNAL OF PHYSIOLOGY, 2009, 52 (05) :316-324

[7]

Iaremii I N, 2002, Eksp Klin Farmakol, V65, P57

[8] Pharmacological therapy for acute respiratory distress syndrome [J].

Jain, R ;

DalNogare, A .

MAYO CLINIC PROCEEDINGS, 2006, 81 (02) :205-212

[9] Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-κB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages [J].

Jung, Chang Hwa ;

Kim, Ji Hye ;

Hong, Myung Hee ;

Seog, Ho Moon ;

Oh, Seong Hoon ;

Lee, Pan Jae ;

Kim, Gyung Jun ;

Kim, Hyung Min ;

Um, Jae Young ;

Ko, Seong-Gyu .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 110 (03) :490-497

[10]

Kelly G S, 2001, Altern Med Rev, V6, P293

← 1 2 3 →