Zephgrabetaine: A New Betaine-type Amaryllidaceae Alkaloid from Zephyranthes grandiflora

被引：0

作者：

Katoch, Deepali ^{[1
]}

Kumar, Dharmesh ^{[2
]}

Sharma, Upendra ^{[1
]}

Kumar, Neeraj ^{[1
]}

Padwad, Yogendra S. ^{[2
]}

Lal, Brij ^{[3
]}

Singh, Bikram ^{[1
]}

机构：

[1] CSIR Inst Himalayan Bioresource Technol, Nat Plant Prod Div, Palampur 176061, Himachal Prades, India

[2] CSIR Inst Himalayan Bioresource Technol, Div Biotechnol, Palampur 176061, Himachal Prades, India

[3] CSIR Inst Himalayan Bioresource Technol, Biodivers Div, Palampur 176061, Himachal Prades, India

来源：

NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 02期

关键词：

Amaryllidaceae alkaloids; Betaine; Cytotoxic activity; Zephyranthes grandiflora; GC-MS; CHOLINESTERASE; LYCORINE; DERIVATIVES; CHEMISTRY; GC/MS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.

引用

页码：161 / 164

页数：4

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