Pd-Catalyzed Regioselective Allylation of Mono- and Disubstituted Hydrazines

被引：15
|
作者：
Tsupova, Svetlana [1 ]
Maeeorg, Uno [1 ]
机构：
[1] Univ Tartu, Dept Chem, EE-50411 Tartu, Estonia
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 13期
关键词：
HYDROAMINATION; HYDROXYLAMINE; METHODOLOGY; ALKYLATION;
D O I：
10.1021/ol4014798
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed allylation of hydrazines using allyl alcohols is reported. This highly efficient protocol furnishes monoallylated hydrazines selectively, in 27-99% yields. Following an optimization of the reaction conditions and of the Pd-ligands, the allylations of both mono- and disubstituted hydrazines were investigated, as well as the effects of C2-substitution on the allylating agent. Of particular interest, a novel method for the selective monoallylation of monosubstituted hydrazines is demonstrated.
引用
收藏
页码：3381 / 3383
页数：3
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