Preimplantation genetic screening to improve in vitro fertilization pregnancy rates: a prospective randomized controlled trial

被引：48
作者：
Mersereau, Jennifer E. [1 ]
Ergament, Eugene P. [2 ]
Zhang, Xingqi [3 ]
Milad, Magdy P. [3 ]
机构：
[1] Univ Calif San Francisco, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, San Francisco, CA 94143 USA
[2] NW Reprod Genet, Chicago, IL USA
[3] Northwestern Univ, Feinberg Sch Med, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Chicago, IL 60611 USA
来源：
FERTILITY AND STERILITY | 2008年 / 90卷 / 04期
关键词：
D O I：
10.1016/j.fertnstert.2007.08.010
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This prospective randomized controlled pilot trial was designed to evaluate whether prescreening embryos for aneuploidy can improve clinical outcomes in infertile patients undergoing IVF, without limiting to poor prognosis patients. Although there was no statistically significant improvement in live birth rates or implantation rates in this pilot study, there was a trend toward improved clinical outcomes, indicating that future multicenter randomized trials are needed.
引用
收藏
页码：1287 / 1289
页数：3
相关论文
共 50 条
[41]   Intent to treat analysis of in vitro fertilization and preimplantation genetic screening versus expectant management in patients with recurrent pregnancy loss [J].
Murugappan, Gayathree ;
Shahine, Lora K. ;
Perfetto, Candice O. ;
Hickok, Lee R. ;
Lathi, Ruth B. .
HUMAN REPRODUCTION, 2016, 31 (08) :1668-1674
[42]   A randomized controlled trial of a video to improve patient knowledge of genetic testing options in pregnancy [J].
Mulla, Bethany ;
Chang, Olivia H. ;
Modest, Anna M. ;
Hacker, Michele R. ;
Marchand, Karen F. ;
O'Brien, Karen E. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2018, 218 (01) :S161-S161
[43]   Significantly increased implantation and clinical pregnancy rates following PGS: a prospective randomized controlled trial of 24 chromosome aneuploidy screening [J].
Treff, N. R. ;
Tao, X. ;
Taylor, D. ;
Levy, B. ;
Ferry, K. M. ;
Scott, R. T., Jr. .
HUMAN REPRODUCTION, 2011, 26 :I287-I287
[44]   Does Preimplantation Genetic Screening (PGS) Improve Blastocyst Implantation Rates (IR)? [J].
Rubin, Jessica ;
Kaskar, Khalied ;
Woodard, Terri ;
Gibbons, William .
REPRODUCTIVE SCIENCES, 2017, 24 :295A-295A
[45]   Ultra-long administration of GnRH-a before in vitro fertilization does not improve the clinical pregnancy rate in women with mild endometriosis. A prospective, randomized, controlled trial [J].
Kaponis, A. ;
Panagodimou, E. ;
Hadjopoulos, G. ;
Paschopoulos, M. ;
Georgiou, I. ;
Paraskevaidis, V. ;
Zikopoulos, K. ;
Tsiveriotis, K. ;
Taniguchi, F. ;
Adonakis, G. ;
Harada, T. .
HUMAN REPRODUCTION, 2020, 35 :139-139
[46]   Comparative analysis of pregnancy outcomes in preimplantation genetic testing for aneuploidy and conventional in vitro fertilization and embryo transfer: a stratified examination on the basis of the quantity of oocytes and blastocysts from a multicenter randomized controlled trial [J].
Hu, Min ;
Liu, Mingxi ;
Tian, Siqi ;
Guo, Ling ;
Zang, Zhaowen ;
Chen, Zi-Jiang ;
Li, Yan .
FERTILITY AND STERILITY, 2024, 122 (01) :121-130
[47]   The association of obesity with euploidy rates in women undergoing in vitro fertilization with preimplantation genetic testing [J].
Stephanie Hallisey ;
Reeva Makhijani ;
Jeffrey Thorne ;
Prachi Godiwala ;
John Nulsen ;
Claudio Benadiva ;
Daniel Grow ;
Lawrence Engmann .
Journal of Assisted Reproduction and Genetics, 2022, 39 :2521-2528
[48]   The association of obesity with euploidy rates in women undergoing in vitro fertilization with preimplantation genetic testing [J].
Hallisey, Stephanie ;
Makhijani, Reeva ;
Thorne, Jeffrey ;
Godiwala, Prachi ;
Nulsen, John ;
Benadiva, Claudio ;
Grow, Daniel ;
Engmann, Lawrence .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2022, 39 (11) :2521-2528
[49]   Comparative Analysis of Pregnancy Outcomes in Preimplantation Genetic Testing for Aneuploidy and Conventional In Vitro Fertilization and Embryo Transfer: A Stratified Examination on the Basis of the Quantity of Oocytes and Blastocysts From a Multicenter Randomized Controlled Trial [J].
Hu, Min ;
Liu, Mingxi ;
Tian, Siqi ;
Guo, Ling ;
Zang, Zhaowen ;
Chen, Zi-Jiang ;
Li, Yan .
OBSTETRICAL & GYNECOLOGICAL SURVEY, 2024, 79 (11) :650-651
[50]   Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening [J].
Kim, Min Kyoung ;
Park, Jae Kyun ;
Jeon, Yunmi ;
Seok, Su Hee ;
Chang, Eun Mi ;
Lee, Woo Sik .
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM, 2019, 46 (01) :22-29
12345