Stem cell modeling of lipid genetics

被引：1
|
作者：
Musunuru, Kiran [1 ,2 ]
机构：
[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN LIPIDOLOGY | 2018年 / 29卷 / 02期
关键词：
genetics; hepatocytes; lipids; lipoproteins; stem cells; HEPATOCYTE-LIKE CELLS; DISEASE; HYPERCHOLESTEROLEMIA; DIFFERENTIATION; LOCUS; SORT1; MACROPHAGES; POPULATION; SECRETION; LIVER;
D O I：
10.1097/MOL.0000000000000490
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purpose of review To summarize recent advances with respect to the use of human pluripotent stem cells to study the genetics of blood lipid traits. Recent findings Human pluripotent stem cell models have been used to elucidate the mechanisms by which genes contribute to dyslipidemia, to discover new lipid-related DNA variants and genes, and to perform drug screens. Summary In addition to enabling a better understanding of the genetic basis of lipid metabolism, human pluripotent stem cells are identifying potential therapeutic targets as well as potential therapies.
引用
收藏
页码：151 / 155
页数：5
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