Stem cell modeling of lipid genetics

被引：1
作者：
Musunuru, Kiran [1 ,2 ]
机构：
[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN LIPIDOLOGY | 2018年 / 29卷 / 02期
关键词：
genetics; hepatocytes; lipids; lipoproteins; stem cells; HEPATOCYTE-LIKE CELLS; DISEASE; HYPERCHOLESTEROLEMIA; DIFFERENTIATION; LOCUS; SORT1; MACROPHAGES; POPULATION; SECRETION; LIVER;
D O I：
10.1097/MOL.0000000000000490
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purpose of review To summarize recent advances with respect to the use of human pluripotent stem cells to study the genetics of blood lipid traits. Recent findings Human pluripotent stem cell models have been used to elucidate the mechanisms by which genes contribute to dyslipidemia, to discover new lipid-related DNA variants and genes, and to perform drug screens. Summary In addition to enabling a better understanding of the genetic basis of lipid metabolism, human pluripotent stem cells are identifying potential therapeutic targets as well as potential therapies.
引用
收藏
页码：151 / 155
页数：5
相关论文
共 50 条
  • [1] Genetics of lipid disorders
    Pirruccello, James
    Kathiresan, Sekar
    CURRENT OPINION IN CARDIOLOGY, 2010, 25 (03) : 238 - 242
  • [2] Modeling the Prostate Stem Cell Niche: An Evaluation of Stem Cell Survival and Expansion In Vitro
    Lang, Shona H.
    Anderson, Elizabeth
    Fordham, Robert
    Collins, Anne T.
    STEM CELLS AND DEVELOPMENT, 2010, 19 (04) : 537 - 546
  • [3] Stem Cell-based Therapy Strategy for Hepatic Fibrosis by Targeting Intrahepatic Cells
    Deng, Yaxin
    Xia, Bin
    Chen, Zhongmin
    Wang, Fuping
    Lv, Yonggang
    Chen, Guobao
    STEM CELL REVIEWS AND REPORTS, 2022, 18 (01) : 77 - 93
  • [4] Atherosclerosis, Inflammation, Genetics, and Stem Cells: 2012 Update
    Goldschmidt-Clermont, Pascal J.
    Dong, Chunming
    Seo, David M.
    Velazquez, Omaida C.
    CURRENT ATHEROSCLEROSIS REPORTS, 2012, 14 (03) : 201 - 210
  • [5] Stochastic modeling of stem-cell dynamics with control
    Sun, Zheng
    Komarova, Natalia L.
    MATHEMATICAL BIOSCIENCES, 2012, 240 (02) : 231 - 240
  • [6] Human epidermal stem cell differentiation is modulated by specific lipid subspecies
    Rudan, Matteo Vietri
    Mishra, Ajay
    Klose, Christian
    Eggert, Ulrike S.
    Watt, Fiona M.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (36) : 22173 - 22182
  • [7] Innate immunity in stem cell-derived hepatocytes
    Fischer, Lena
    Hay, David C.
    O'Farrelly, Cliona
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2018, 373 (1750)
  • [8] Epigenome-Wide Association Study of Fasting Blood Lipids in the Genetics of Lipid-Lowering Drugs and Diet Network Study
    Irvin, Marguerite R.
    Zhi, Degui
    Joehanes, Roby
    Mendelson, Michael
    Aslibekyan, Stella
    Claas, Steven A.
    Thibeault, Krista S.
    Patel, Nikita
    Day, Kenneth
    Jones, Lindsay Waite
    Liang, Liming
    Chen, Brian H.
    Yao, Chen
    Tiwari, Hemant K.
    Ordovas, Jose M.
    Levy, Daniel
    Absher, Devin
    Arnett, Donna K.
    CIRCULATION, 2014, 130 (07) : 565 - +
  • [9] Pancreatic Diseases: Genetics and Modeling Using Human Pluripotent Stem Cells
    Lee, Yuri
    Lee, Kihyun
    INTERNATIONAL JOURNAL OF STEM CELLS, 2024, 17 (03) : 253 - 269
  • [10] Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation
    Ramosaj, Mergim
    Madsen, Sofia
    Maillard, Vanille
    Scandella, Valentina
    Sudria-Lopez, Daniel
    Yuizumi, Naoya
    Telley, Ludovic
    Knobloch, Marlen
    NATURE COMMUNICATIONS, 2021, 12 (01)
12345