Stem cell modeling of lipid genetics

被引：1
|
作者：
Musunuru, Kiran [1 ,2 ]
机构：
[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN LIPIDOLOGY | 2018年 / 29卷 / 02期
关键词：
genetics; hepatocytes; lipids; lipoproteins; stem cells; HEPATOCYTE-LIKE CELLS; DISEASE; HYPERCHOLESTEROLEMIA; DIFFERENTIATION; LOCUS; SORT1; MACROPHAGES; POPULATION; SECRETION; LIVER;
D O I：
10.1097/MOL.0000000000000490
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purpose of review To summarize recent advances with respect to the use of human pluripotent stem cells to study the genetics of blood lipid traits. Recent findings Human pluripotent stem cell models have been used to elucidate the mechanisms by which genes contribute to dyslipidemia, to discover new lipid-related DNA variants and genes, and to perform drug screens. Summary In addition to enabling a better understanding of the genetic basis of lipid metabolism, human pluripotent stem cells are identifying potential therapeutic targets as well as potential therapies.
引用
收藏
页码：151 / 155
页数：5
相关论文
共 50 条
  • [1] Detoxifying chemotherapy with genetics-guided stem cell modeling: A personalized affair
    Brooks, Dominique L.
    Musunuru, Kiran
    CELL STEM CELL, 2021, 28 (12) : 2039 - 2040
  • [2] Neural stem cell genetics and proteomics
    Komblum, HI
    Easterday, M
    Shoemaker, L
    Jackson, R
    Ou, J
    Paucar, A
    Geschwind, DH
    JOURNAL OF NEUROCHEMISTRY, 2003, 85 : 102 - 102
  • [3] Genetics of Gonadal Stem Cell Renewal
    Greenspan, Leah Joy
    de Cuevas, Margaret
    Matunis, Erika
    ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31, 2015, 31 : 291 - 315
  • [4] The new genetics: Stem cell research and cloning
    Gearhart, John D.
    Viewing New Creations with Anabaptist Eyes: Ethics of Biotechnology, 2005, : 21 - 34
  • [5] Basic questions on genetics, stem cell research, and cloning
    不详
    ISSUES IN LAW & MEDICINE, 2005, 20 (03) : 293 - 293
  • [6] Preimplantation genetics - Improving access to stem cell therapy
    Kuliev, A
    Rechitsky, S
    Tur-Kaspa, I
    Verlinsky, Y
    COOLEY'S ANEMIA EIGHTH SYMPOSIUM, 2005, 1054 : 223 - 227
  • [7] Modeling Steatosis and Lipid-Mediated Cell Injury Using Induced Pluripotent Stem Cell-Derived-Hepatocytes
    Irudayam, Joseph Ignatius
    Contreras, Deisy
    French, Samuel
    Arumugaswami, Vaithilingaraja
    FASEB JOURNAL, 2015, 29
  • [8] MODELING LIPID METABOLISM OF CORONARY ARTERY DISEASE PATIENTS WITH INDUCED PLURIPOTENT STEM CELL DERIVED HEPATOCYTES
    Alexanova, A.
    Viiri, L.
    Laaksonen, R.
    Kiamehr, M.
    Aalto-Setala, K.
    ATHEROSCLEROSIS, 2019, 287 : E118 - E119
  • [9] Lipid Metabolism Greases the Stem Cell Engine
    Folmes, Clifford D. L.
    Park, Sungjo
    Terzic, Andre
    CELL METABOLISM, 2013, 17 (02) : 153 - 155
  • [10] Pancreatic Diseases: Genetics and Modeling Using Human Pluripotent Stem Cells
    Lee, Yuri
    Lee, Kihyun
    INTERNATIONAL JOURNAL OF STEM CELLS, 2024, 17 (03) : 253 - 269
12345