Review of squamous premalignant vulvar lesions

被引：150
作者：
van de Nieuwenhof, H. P. [1 ]
van der Avoort, I. A. M. [1 ]
de Hullu, J. A. [1 ]
机构：
[1] Radboud Univ Nijmegen, Dept Obstet & Gynaecol, Ctr Med, NL-6500 HB Nijmegen, Netherlands
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2008年 / 68卷 / 02期
关键词：
Vulvar squamous cell carcinoma; Vulvar intraepithelial neoplasia; Lichen sclerosus; HPV; Malignant potential;
D O I：
10.1016/j.critrevonc.2008.02.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Vulvar squamous cell carcinoma (SCC) develops following two different pathways, which have their own premalignant lesions. In the absence of human papilloma virus (HPV), vulvar SCC can develop in a background of lichen sclerosus (LS), differentiated vulvar intraepithelial neoplasia (VIN) or both. The other pathway leading to vulvar SCC is associated with HPV and the HPV-associated premalignancy is usual VIN. In this review we will discuss the history, epidemiology, aetiology, histology, clinical characteristics, treatment options, malignant potential and prevention strategies of the three squamous premalignant vulvar lesions. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：131 / 156
页数：26
相关论文
共 213 条
[1]  
Abdel-Hady ES, 2001, CANCER RES, V61, P192
[2]   Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers [J].
Abdulkarim, B ;
Sabri, S ;
Deutsch, E ;
Chagraoui, H ;
Maggiorella, L ;
Thierry, J ;
Eschwege, F ;
Vainchenker, W ;
Chouaïb, S ;
Bourhis, J .
ONCOGENE, 2002, 21 (15) :2334-2346
[3]   HISTOLOGICAL EVIDENCE FOR SPIROCHETAL ORIGIN OF MORPHEA AND LICHEN SCLEROSUS-ET-ATROPHICANS [J].
ABERER, E ;
STANEK, G .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1987, 9 (05) :374-379
[4]  
Abramov Y, 1996, Obstet Gynecol Surv, V51, P193, DOI 10.1097/00006254-199603000-00023
[5]   Cancer risk following organ transplantation:: a nationwide cohort study in Sweden [J].
Adami, J ;
Gäbel, H ;
Lindelöf, B ;
Ekström, K ;
Rydh, B ;
Glimelius, B ;
Ekbom, A ;
Adami, HO ;
Granath, F .
BRITISH JOURNAL OF CANCER, 2003, 89 (07) :1221-1227
[6]  
Ahr A, 2006, Zentralbl Gynakol, V128, P347, DOI 10.1055/s-2006-942280
[7]   Vulvar squamous cell carcinoma in young women: A clinicopathologic study of 21 cases [J].
Al-Ghamdi, A ;
Freedman, D ;
Miller, D ;
Poh, C ;
Rosin, M ;
Zhang, L ;
Gilks, CB .
GYNECOLOGIC ONCOLOGY, 2002, 84 (01) :94-101
[8]  
ANDERSEN BL, 1988, OBSTET GYNECOL, V71, P15
[9]   INTRAEPITHELIAL NEOPLASIA IN THE VULVAR REGION [J].
ANDREASSON, B ;
BOCK, JE .
GYNECOLOGIC ONCOLOGY, 1985, 21 (03) :300-305
[10]   Tacrolimus ointment for the treatment of vulvar lichen sclerosus [J].
Assmann, T ;
Becker-Wegerich, P ;
Grewe, M ;
Megahed, M ;
Ruzicka, T .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 48 (06) :935-937
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