Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

被引：132

作者：

Murray, Peter J. ^{[1
,2
]}

Smale, Stephen T. ^{[3
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[3] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA USA

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 10期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; TOLL-LIKE RECEPTORS; GENE-SPECIFIC CONTROL; ANTIINFLAMMATORY RESPONSE; SOCS PROTEINS; PROTECTS MICE; ACTIVATION; EXPRESSION; CYTOKINE; TRANSCRIPTION;

D O I：

10.1038/ni.2391

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of Toll-like receptor (TLR) signaling and related pathways by microbial products drives inflammatory responses, host-defense pathways and adaptive immunity. The cost of excessive inflammation is cell and tissue damage, an underlying cause of many acute and chronic diseases. Coincident with activation of TLR signaling, a plethora of anti-inflammatory pathways and mechanisms begin to modulate inflammation until tissue repair is complete. Whereas most studies have focused on the signaling components immediately downstream of the TLRs, this Review summarizes the different levels of anti-inflammatory pathways that have evolved to abate TLR signaling and how they are integrated to prevent cell and tissue destruction.

引用

页码：916 / 924

页数：9

共 119 条

[1] TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils [J].

Ajibade, Adebusola Alagbala ;

Wang, Qinfu ;

Cui, Jun ;

Zou, Jia ;

Xia, Xiaojun ;

Wang, Mingjun ;

Tong, Yanzheng ;

Hui, Wei ;

Liu, Dou ;

Su, Bing ;

Wang, Helen Y. ;

Wang, Rong-Fu .

IMMUNITY, 2012, 36 (01) :43-54

[2] Human genetics of infectious diseases: between proof of principle and paradigm [J].

Alcais, Alexandre ;

Abel, Laurent ;

Casanova, Jean-Laurent .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) :2506-2514

[3] The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immuneresponse [J].

Alexander, WS ;

Hilton, DJ .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :503-529

[4] The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [J].

Ananieva, Olga ;

Darragh, Joanne ;

Johansen, Claus ;

Carr, Julia M. ;

McIlrath, Joanne ;

Park, Jin Mo ;

Wingate, Andrew ;

Monk, Claire E. ;

Toth, Rachel ;

Santos, Susana G. ;

Iversen, Lars ;

Arthur, J. Simon C. .

NATURE IMMUNOLOGY, 2008, 9 (09) :1028-1036

[5] Post-transcriptional regulons coordinate the initiation and resolution of inflammation [J].

Anderson, Paul .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (01) :24-35

[6] Reflex Principles of Immunological Homeostasis [J].

Andersson, Ulf ;

Tracey, Kevin J. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 :313-335

[7] A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response [J].

Ashida, Hiroshi ;

Kim, Minsoo ;

Schmidt-Supprian, Marc ;

Ma, Averil ;

Ogawa, Michinaga ;

Sasakawa, Chihiro .

NATURE CELL BIOLOGY, 2010, 12 (01) :66-U164

[8] Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells [J].

Baetz, A ;

Frey, M ;

Heeg, K ;

Dalpke, AH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (52) :54708-54715

[9] Bcl-6 and NF-κB cistromes mediate opposing regulation of the innate immune response [J].

Barish, Grant D. ;

Yu, Ruth T. ;

Karunasiri, Malith ;

Ocampo, Corinne B. ;

Dixon, Jesse ;

Benner, Chris ;

Dent, Alexander L. ;

Tangirala, Rajendra K. ;

Evans, Ronald M. .

GENES & DEVELOPMENT, 2010, 24 (24) :2760-2765

[10] CONSTITUTIVE NF-KAPPA-B ACTIVATION, ENHANCED GRANULOPOIESIS, AND NEONATAL LETHALITY IN I-KAPPA-B-ALPHA-DEFICIENT MICE [J].

BEG, AA ;

SHA, WC ;

BRONSON, RT ;

BALTIMORE, D .

GENES & DEVELOPMENT, 1995, 9 (22) :2736-2746

← 1 2 3 4 5 6 7 8 9 10 →