New Insights into Anticarcinogenic Properties of Adiponectin: A Potential Therapeutic Approach in Breast Cancer?

被引：23
作者：
Delort, Laetitia [1 ,2 ]
Jarde, Thierry [1 ,2 ]
Dubois, Virginie [1 ,2 ]
Vasson, Marie-Paule [1 ,2 ,3 ]
Caldefie-Chezet, Florence [1 ,2 ]
机构：
[1] Univ Auvergne, Clermont Univ, UFR Pharm, Lab SVFp, F-63000 Clermont Ferrand, France
[2] INRA, ECRIN, CRNH Auvergne, UMR 1019, F-63000 Clermont Ferrand, France
[3] Ctr Jean Perrin, Unite Nutr, F-63003 Clermont Ferrand, France
来源：
ADIPONECTIN | 2012年 / 90卷
关键词：
ACTIVATED RECEPTOR-GAMMA; PLASMA ADIPONECTIN; SERUM ADIPONECTIN; PPAR-GAMMA; CELL-PROLIFERATION; IN-VITRO; BINDING PROTEIN; ADIPOSE-TISSUE; OBESE WOMEN; GROWTH;
D O I：
10.1016/B978-0-12-398313-8.00015-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity is a recognized breast cancer risk factor in postmenopausal women. A recent hypothesis suggests a major role for adipose tissue in carcinogenesis. During many years, the adipose tissue was only considered as a fat storage of energy. This tissue is now described as an endocrine organ secreting a large range of molecules called adipokines. Among these adipokines, adiponectin may play a major role in breast cancer. Plasma adiponectin levels were found to be decreased in cases of breast cancer and in obese patients. Adiponectin may act directly on breast cancer cells by inhibiting proliferation and angiogenesis or by stimulating apoptosis. Increasing adiponectin levels may be of major importance in the prevention and/or the treatment of breast cancer. This therapeutic approach may be of particular significance for obese patients. The beneficial effects of adiponectin and its possible therapeutic applications will be discussed in this review.
引用
收藏
页码：397 / 417
页数：21
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