Significance of serum uric acid in patients with chronic respiratory failure treated with non-invasive positive pressure ventilation

被引：13

作者：

Kadowaki, Toru ^{[1
]}

Hamada, Hironobu ^{[1
]}

Yokoyama, Akihito ^{[2
]}

Abe, Masahiro ^{[3
]}

Nishimura, Kazutaka ^{[3
]}

Kohno, Nobuoki ^{[2
]}

Inata, Junya ^{[4
]}

Kuraoka, Toshihiko ^{[4
]}

Moritani, Chie ^{[5
]}

Higaki, Jitsuo ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Integrated Med & Informat, Matsuyama, Ehime 790, Japan

[2] Hiroshima Univ, Dept Mol & Internal Med, Grad Sch Biomed Sci, Hiroshima, Japan

[3] Ehime Natl Hosp, Dept Resp Med, Toon, Japan

[4] Yoshijima Hosp, Federat Natl Publ Serv, Personnel Mutual Aid Assoc, Dept Internal Med, Hiroshima, Japan

[5] Asa Citizens Hosp, Dept Internal Med, Hiroshima, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 11期

关键词：

serum uric acid; chronic respiratory failure; non-invasive positive pressure ventilation; exacerbation;

D O I：

10.2169/internalmedicine.46.6120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose The aim of the study was to evaluate serum uric acid (UA) levels before and after non-invasive positive pressure ventilation (NPPV) to assess the utility of serum UA as an indicator of acute exacerbation of chronic respiratory failure (CRF) in patients treated with NPPV. Methods We analyzed change in the serum UA level in 29 patients with CRF due to restrictive thoracic disease and treated with NPPV. Results After NPPV therapy, PaO2 was significantly increased and PaCO2 was significantly decreased in all patients. Sixty-two percent of patients (18 of 29) showed a decreased serum UA/creatinine (Cr) ratio after NPPV therapy, but, overall, there was no significant change in serum UA/Cr (P = 0.0688). The change in serum UA/Cr was not correlated with the changes in PaO2 and PaCO2 after NPPV. When we compared patients in whom serum UA/Cr decreased (n = 18) with patients in whom serum UA/Cr did not decrease (n = 11), there were significantly fewer patients who suffered CRF exacerbation in the group with a decrease (P = 0.0021). Furthermore, the cumulative proportion (Kaplan-Meier) of patients who did not suffer exacerbation of CRF was significantly higher in the group in which serum UA/Cr decreased (P = 0.0003). Conclusions Our data suggest that serum UA may be a useful clinical indicator of CRF exacerbation in patients treated by NPPV.

引用

页码：691 / 697

页数：7

共 31 条

[1] Uric acid and survival in chronic heart failure - Validation and application in metabolic, functional, and Hemodynamic staging [J].

Anker, SD ;

Doehner, W ;

Rauchhaus, M ;

Sharma, R ;

Francis, D ;

Knosalla, C ;

Davos, CH ;

Cicoira, M ;

Shamim, W ;

Kemp, M ;

Segal, R ;

Osterziel, KJ ;

Leyva, F ;

Hetzer, R ;

Ponikowski, P ;

Coats, AJS .

CIRCULATION, 2003, 107 (15) :1991-1997

[2]

*ATS ERS, ATS ERS COPD GUID

[3]

Bach JR, 2002, NONINVASIVE MECH VEN

[4]

BEERS MF, 1997, FISHMANS PULMONARY D, V2

[5] OVERNIGHT URINARY URIC-ACID - CREATININE RATIO FOR DETECTION OF SLEEP HYPOXEMIA - VALIDATION-STUDY IN CHRONIC OBSTRUCTIVE PULMONARY-DISEASE AND OBSTRUCTIVE SLEEP-APNEA BEFORE AND AFTER TREATMENT WITH NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE [J].

BRAGHIROLI, A ;

SACCO, C ;

ERBETTA, M ;

RUGA, V ;

DONNER, CF .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (01) :173-178

[6] Treatment of chronic respiratory failure in kyphoscoliosis: oxygen or ventilation? [J].

Buyse, B ;

Meersseman, W ;

Demedts, M .

EUROPEAN RESPIRATORY JOURNAL, 2003, 22 (03) :525-528

[7] A COLORIMETRIC METHOD USING URICASE AND PEROXIDASE FOR DETERMINATION OF URIC ACID [J].

DOMAGK, GF ;

SCHLICKE, HH .

ANALYTICAL BIOCHEMISTRY, 1968, 22 (02) :219-&

[8]

FISHMAN AP, 1997, FISHMANS PULMONARY D, V2

[9]

FLETCHER CM, 1952, P ROY SOC MED, V45, P577

[10] EVIDENCE FOR ADENOSINE-TRIPHOSPHATE DEGRADATION IN CRITICALLY-ILL PATIENTS [J].

GRUM, CM ;

SIMON, RH ;

DANTZKER, DR ;

FOX, IH .

CHEST, 1985, 88 (05) :763-767

← 1 2 3 4 →