Three cases of IMP-type metallo-β-lactamase-producing Enterobacter cloacae bloodstream infection in Japan

被引：14

作者：

Hamada, Yohei ^{[1
]}

Watanabe, Koji ^{[2
]}

Tatsuya, Tada ^{[3
]}

Mezaki, Kazuhisa ^{[4
]}

Takeuchi, Sosuke ^{[5
]}

Shimizu, Toshio ^{[6
]}

Kirikae, Teruo ^{[3
]}

Ohmagari, Norio ^{[1
]}

机构：

[1] Natl Ctr Global Hlth & Med, Div Infect Dis, Dis Control & Prevent Ctr, Shinjuku Ku, Tokyo 1628655, Japan

[2] Natl Ctr Global Hlth & Med, AIDS Clin Ctr, Shinjuku Ku, Tokyo 1628655, Japan

[3] Natl Ctr Global Hlth & Med, Dept Infect Dis, Res Inst, Shinjuku Ku, Tokyo 1628655, Japan

[4] Natl Ctr Global Hlth & Med, Dept Clin Lab, Shinjuku Ku, Tokyo 1628655, Japan

[5] Natl Ctr Global Hlth & Med, Dept Internal Med & Neurol, Shinjuku Ku, Tokyo 1628655, Japan

[6] Natl Ctr Global Hlth & Med, Dept Surg, Shinjuku Ku, Tokyo 1628655, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2013年 / 19卷 / 05期

关键词：

Metallo-beta-lactamase; Carbapenemase; Enterobacter cloacae; Bloodstream infection;

D O I：

10.1007/s10156-012-0520-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report three cases of IMP-type metallo-beta-lactamase-producing Enterobacter cloacae bloodstream infection, which showed minimum inhibitory concentration values for imipenem with 2 mu g/ml in all isolates. Although carbapenems were initiated empirically in all cases, two of three cases died. The Clinical and Laboratory Standards Institute lowered the breakpoints of carbapenems for Enterobacteriaceae in 2010. However, the previous breakpoints are still used in many clinical laboratories, which can result in failure to detect carbapenem-resistant Enterobacteriaceae. Therefore, lower breakpoints of carbapenems should be used in clinical settings, and alternative tests for detecting metallo-beta-lactamase such as polymerase chain reaction and immunochromatographic assays may contribute to better detection of carbapenem-resistant isolates.

引用

页码：956 / 958

页数：3

共 13 条

[1]

[Anonymous], 2010, CLSI Document M100-S20

[2]

Arakawa Y, 2000, J CLIN MICROBIOL, V38, P40

[3]

Clinical and Laboratory Standards Institute, 2009, M100S19 CLSI

[4]

Cornaglia G., 2011, Lancet Infect Dis, V11, P381, DOI DOI 10.1016/S1473-3099(11)70056-1

[5] Infections with VIM-1 Metallo-β-Lactamase-Producing Enterobacter cloacae and Their Correlation with Clinical Outcome [J].

Falcone, Marco ;

Mezzatesta, Maria Lina ;

Perilli, Mariagrazia ;

Forcella, Chiara ;

Giordano, Alessandra ;

Cafiso, Viviana ;

Amicosante, Gianfranco ;

Stefani, Stefania ;

Venditti, Mario .

JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (11) :3514-3519

[6] Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention [J].

Gupta, Neil ;

Limbago, Brandi M. ;

Patel, Jean B. ;

Kallen, Alexander J. .

CLINICAL INFECTIOUS DISEASES, 2011, 53 (01) :60-67

[7] Development of an immunochromatographic assay for diagnosing the production of IMP-type metallo-β-lactamases that mediate carbapenem resistance in Pseudomonas [J].

Kitao, Tomoe ;

Miyoshi-Akiyama, Tohru ;

Tanaka, Masashi ;

Narahara, Kenji ;

Shimojima, Masahiro ;

Kirikae, Teruo .

JOURNAL OF MICROBIOLOGICAL METHODS, 2011, 87 (03) :330-337

[8] Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-β-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp. [J].

Lee, K ;

Lim, YS ;

Yong, D ;

Yum, JH ;

Chong, Y .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (10) :4623-4629

[9] Evaluation of the chromogenic Cica-β-Test for detecting extended-spectrum, AmpC and metallo-β-lactamases [J].

Livermore, D. M. ;

Warner, M. ;

Mushtaq, S. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (06) :1375-1379

[10]

Lledo W., 2009, Morbidity and Mortality Weekly Report, V58, P256

← 1 2 →