A convenient method for the one-step synthesis of phosphonic peptides

被引：9
|
作者：
Skorenski, Marcin [1 ]
Oleksyszyn, Jozef [1 ]
Sienczyk, Marcin [1 ]
机构：
[1] Wroclaw Univ Technol, Fac Chem, Div Med Chem & Microbiol, PL-50370 Wroclaw, Poland
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 36期
关键词：
1-Aminoalkylphosphonates; Phosphonic peptides; Amidoalkylation; Amides; Serine protease inhibitors;
D O I：
10.1016/j.tetlet.2013.07.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient method for the synthesis of peptidyl derivatives of 1-aminoalkylphosphonate diaryl esters is presented. Phosphonic peptides were obtained in one step via an amidoalkylation reaction using amides of N-protected amino acids or peptides, triphenyl phosphite, and an appropriate aldehyde. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4975 / 4977
页数：3
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