Synthesis of glycoproteins

被引：447

作者：

Davis, BG ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1021/cr0004310

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The remarkable diversity of techniques available for the construction of glycoproteins is presented. The complexity of synthesis is still an issue but by judicious and combined use of some of the complementary techniques, practical synthesis of complex glycoproteins will be achieved. Since glycosylation has an important role in correct protein folding, it is unlikely to be enough to "just make it", and in this regard the timing of glycosylation and assembly strategy in any synthesis may too become a vital issue.

引用

页码：579 / 601

页数：23

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