Associations of histone deacetylase-2 and histone deacetylase-3 genes with schizophrenia in a Chinese population

被引：9

作者：

Han, Hongzhi ^{[1
,2
]}

Yu, Yaqin ^{[1
]}

Shi, Jieping ^{[1
]}

Yao, Yan ^{[1
]}

Li, Wenjun ^{[1
]}

Kong, Ning ^{[3
]}

Wu, Yanhua ^{[1
]}

Wang, Chong ^{[1
]}

Wang, Shibin ^{[1
]}

Meng, Xiangfei ^{[4
]}

Kou, Changgui ^{[1
]}

机构：

[1] Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Changchun 130021, Peoples R China

[2] Journal Jilin Univ, Dept Med Edit, Changchun, Peoples R China

[3] Jilin Univ, Coll Pharm, Dept Regenerat Med, Changchun 130021, Peoples R China

[4] Univ Saskatchewan, Dept Psychiat, Saskatoon, SK S7N 0W0, Canada

来源：

ASIA-PACIFIC PSYCHIATRY | 2013年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

gene polymorphism; histone deacetylase; schizophrenia; tag single nucleotide polymorphism; REELIN PROMOTER; REPRESSION; FAMILY; EPIGENETICS; GENETICS; COMPLEX; TWIN;

D O I：

10.1111/j.1758-5872.2012.00205.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Introduction To explore the association between histone deacetylase-2 (HDAC2) and histone deacetylase-3 (HDAC3) gene polymorphisms and schizophrenia. Methods A total of 208 family trios consisting of fathers, mothers and affected offspring with schizophrenia were recruited as our subjects. Four tag SNPs on HDAC2 (rs10499080, rs6568819, rs2499618 and rs13204445) and two tag SNPs on HDAC3 (rs11741808, rs2530223) genes were selected. The Mass ARRAY Assay Design software (Sequenom) was used to design amplification and allele specific extension primers. The Hardy-Weinberg equilibrium (HWE) for genotypic distributions was tested using the chi-square goodness-of-fit test. Allelic association for a single tag SNP was analyzed by using family-based association tests including the haplotype-based haplotype relative risk (HHRR) test and the transmission disequilibrium test (TDT). Results The genotypic distributions of HDAC2 SNPs rs6568819, rs2499618 and rs13204445 and HDAC3 SNPs rs11741808 and rs2530223 were all in Hardy-Weinberg equilibrium (0.05). HHRR analysis revealed no associations between the SNPs and schizophrenia (0.05). In addition, the TDT did not show any significant associations between HDAC2 and HDAC3 SNPs and schizophrenia (0.05). Discussion HDAC2 and HDAC3 might not be associated with schizophrenia in the Chinese population.

引用

页码：11 / 16

页数：6

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