PlexinD1 Glycoprotein Controls Migration of Positively Selected Thymocytes into the Medulla

被引：105

作者：

Choi, Young I. ^{[1
,2
]}

Duke-Cohan, Jonathan S. ^{[1
,2
]}

Ahmed, Wesam B. ^{[1
]}

Handley, Maris A. ^{[1
]}

Mann, Fanny ^{[3
]}

Epstein, Jonathan A. ^{[4
]}

Clayton, Linda K. ^{[1
,2
,5
]}

Reinherz, Ellis L. ^{[1
,2
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Immunobiol Lab, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Univ Aix Marseille 2, CNRS, UMR 6216, Inst Marseille Luminy, F-13288 Marseille 09, France

[4] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[5] Univ Penn, Cardiovasc Inst, Philadelphia, PA 19104 USA

来源：

IMMUNITY | 2008年 / 29卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.immuni.2008.10.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4(+)CD8(+) double positive (DP) thymocytes. PlexinD1 expression was further affected by the engagement of T cell receptor complex. Activation of plexinD1 via the ligand, semaphorin 3E, repressed CCL25 chemokine signaling via its receptor CCR9 in CD69(+) thymocytes. In the absence of plexinD1, CD69(+) thymocytes remained in the cortex, maturing to form ectopic single positive (SP) thymocyte clusters in Plxnd1-deficient fetal liver cell-transplanted mice. As a consequence, the boundary between DID and SP thymocytes; at corticomedullary junctions was disrupted and medullary structures formed under the thymic capsule. These results demonstrate the importance of plexinD1 in directing migration of maturing thymocytes via modulation of biological responses to chemokine gradients.

引用

页码：888 / 898

页数：11

共 40 条

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