On the normalization of cerebral blood flow

被引：7

作者：

Guibert, Romain ^{[1
,2
,3
,4
]}

Fonta, Caroline ^{[3
,4
]}

Esteve, Francois ^{[5
,6
]}

Plouraboue, Franck ^{[1
,2
]}

机构：

[1] Univ Toulouse, Inst Mecan Fluides Toulouse, INPT, UPS,IMFT, Toulouse, France

[2] CNRS, IMFT, Toulouse, France

[3] Univ Toulouse, UPS, Ctr Rech Cerveau & Cognit, Toulouse, France

[4] CNRS, CerCo, Toulouse, France

[5] INSERM, Grenoble Inst Neurosci, U836, Grenoble 9, France

[6] European Synchrotron Radiat Facil, Med Beamline ID17, F-38043 Grenoble 9, France

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2013年 / 33卷 / 05期

关键词：

brain imaging; brain perfusion; computed tomography; hemodynamics; microcirculation; ULTRAFAST COMPUTED-TOMOGRAPHY; MRI BOLUS TRACKING; MICROVASCULAR NETWORKS; CBV MEASUREMENTS; VOLUME;

D O I：

10.1038/jcbfm.2013.39

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cerebral blood flow (CBF) is the most common parameter for the quantification of brain's function. Literature data indicate a widespread dispersion of values that might be related :to some differences in the measurement conditions that are not properly taken into account in CBF evaluation. Using recent high-resolution imaging of the complete cortical microvasculature of primate brain, we perform extensive numerical evaluation of the cerebral perfusion. We show that blood perfusion associated with intravascular tracers should be normalized by the surface of the voxel rather than by its volume and we consistently test this result on the available literature data.

引用

页码：669 / 672

页数：4

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