Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: The EDEN mother-child cohort study

被引:78
作者
Menai, Mehdi [2 ,3 ]
Heude, Barbara [2 ,3 ]
Slama, Remy [4 ]
Forhan, Anne [2 ,3 ]
Sahuquillo, Josiane [2 ,3 ]
Charles, Marie-Aline [2 ,3 ]
Yazbeck, Chadi [1 ,2 ,3 ]
机构
[1] Hop Bichat Claude Bernard, APHP, Dept Obstet & Gynecol, F-75018 Paris, France
[2] INSERM CESP Ctr Rech Epidemiol & Sante Populat, U1018, Team Epidemiol Obes Diabet & Renal Dis Life Cours, F-94807 Villejuif, France
[3] Univ Paris Sud, UMRS 1018, F-94807 Villejuif, France
[4] Inst Albert Bonniot, Avenir Team Environm Epidemiol Appl Fecund & Repr, INSERM, F-38042 Grenoble 9, France
关键词
Birth weight; Cadmium; Cohort; Fetal growth; Environmental exposure; Tobacco use; Toxicology; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2; CORD BLOOD; EXPOSURE; LEAD; PLACENTA; WOMEN; EXPRESSION; METALS; LEVEL;
D O I
10.1016/j.reprotox.2012.09.002
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The objective of this study is to investigate the potential effect of maternal environmental cadmium (Cd) exposure on birth weight and fetal growth restriction (FGR). A total of 901 pregnant women from the EDEN cohort study were enrolled from two maternity units. Blood Cd was measured at mid-pregnancy and associations with birth weight and FGR were analyzed. Maternal Cd levels were associated with reduced birth weight in the offspring of women who smoked during pregnancy (b = -113.7; p=0.001). Smoking during pregnancy and maternal blood Cd concentrations had comparable effects on FGR incidence (OR 1.89; 95% CI: 1.00-3.58 and OR= 1.41; 95% CI: 1.00-1.99, respectively). This study highlights the effect of Cd toxicity on fetal growth through the probable accumulation and transmission of this metal through the placenta. The close relationship between blood Cd levels and smoking habits indicates that Cd may be a relevant biomarker for smoking toxicity on fetal development. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:622 / 627
页数:6
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