Knockdown Screens to Knockout HIV-1

被引：89

作者：

Goff, Stephen P. ^{[1
]}

机构：

[1] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

CELL | 2008年 / 135卷 / 03期

关键词：

D O I：

10.1016/j.cell.2008.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three recent screens use siRNAs to identify host genes that are critical for HIV-1 replication. These screens have uncovered hundreds of human genes not previously known to be commandeered by the virus during infection. Although some caveats remain, this screening approach opens up a new landscape of viral-host interactions for future exploration.

引用

页码：417 / 420

页数：4

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