Valproate as a treatment for dopamine dysregulation syndrome (DDS) in Parkinson's disease

被引：27

作者：

Sriram, Ashok ^{[1
]}

Ward, Herbert E. ^{[2
]}

Hassan, Anhar ^{[1
]}

Iyer, Sanjay ^{[3
]}

Foote, Kelly D. ^{[4
]}

Rodriguez, Ramon L. ^{[1
]}

McFarland, Nikolaus R. ^{[1
]}

Okun, Michael S. ^{[1
,4
]}

机构：

[1] Ctr Movement Disorders & Neurorestorat, Dept Neurol, Gainesville, FL 32611 USA

[2] Ctr Movement Disorders & Neurorestorat, Dept Psychiat, Gainesville, FL 32611 USA

[3] CMC Neurol, Charlotte, NC USA

[4] Ctr Movement Disorders & Neurorestorat, Dept Neurosurg, Gainesville, FL 32611 USA

来源：

JOURNAL OF NEUROLOGY | 2013年 / 260卷 / 02期

关键词：

Dopamine dysregulation syndrome; Parkinson's disease; Impulse control disorder; Valproic acid; Dominion; HEDONISTIC HOMEOSTATIC DYSREGULATION; IMPULSE-CONTROL DISORDERS; DEEP BRAIN-STIMULATION; REPLACEMENT THERAPIES; SUBTHALAMIC NUCLEUS; SODIUM VALPROATE; COMPULSIVE USE; ACID; INHIBITION; NEURONS;

D O I：

10.1007/s00415-012-6669-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It has been previously well established that the use of dopaminergic agents in Parkinson's disease may contribute to behavioral disturbances such as dopamine dysregulation syndrome (DDS), impulse control disorders (ICD), and punding. ICD and punding have been most commonly addressed by reducing dose or by discontinuing the use of a dopamine agonist. Treatment of DDS has proven more challenging, and to date there has been no standard approach. In this paper, we review a series of four patients who met criteria for DDS, who were all refractory to medication adjustments. The DDS symptoms responded by the addition of valproic acid in all cases.

引用

页码：521 / 527

页数：7

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