-383 A/C tumor necrosis factor receptor 1 polymorphism and ankylosing spondylitis in Mexicans: a preliminary study

被引：13

作者：

Guadalupe Corona-Sanchez, Esther ^{[1
,2
]}

Francisco Munoz-Valle, Jose ^{[1
,2
]}

Gonzalez-Lopez, Laura ^{[3
,4
]}

Dolores Sanchez-Hernandez, Julia

Vazquez-Del Mercado, Monica ^{[2
]}

Ontiveros-Mercado, Heriberto ^{[2
]}

Huerta, Miguel ^{[5
]}

Trujillo, Xochitl ^{[5
]}

Daniel Rocha-Munoz, Alberto ^{[3
]}

Celis, Alfredo ^{[4
]}

Ortega-Flores, Ricardo ^{[6
]}

Ivan Gamez-Nava, Jorge ^{[1
,4
]}

机构：

[1] Hosp Especialidades Ctr Med Nacl Occidente, IMSS, Sect Musculoskeletal Dis & Autoimmun, Clin Epidemiol Res Unit, Guadalajara, Jalisco, Mexico

[2] Univ Guadalajara, Inst Invest Reumatol & Sistema Musculo Esquelet, Dept Biol Mol & Genom, Ctr Univ Ciencias Salud, Guadalajara 44340, Jalisco, Mexico

[3] Hosp Gen Reg 110, IMSS, Dept Internal Med Rheumatol, Guadalajara, Jalisco, Mexico

[4] Univ Guadalajara, Postgrad Program Publ Hlth, Ctr Univ Ciencias Salud, Guadalajara 44340, Jalisco, Mexico

[5] Ctr Univ Invest Biomed, Unidad Invest Enrico Stefani, Colima, Mexico

[6] Hosp Gen Reg 110, Cent Lab, IMSS, Guadalajara, Jalisco, Mexico

来源：

RHEUMATOLOGY INTERNATIONAL | 2012年 / 32卷 / 08期

关键词：

Ankylosing spondylitis; Tumor necrosis factor receptor 1; Genetic polymorphism; Case-control studies; TNF; GENES;

D O I：

10.1007/s00296-011-1997-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study was to evaluate the differences in allele and genotype frequencies of -383 tumor necrosis factor receptor 1 (TNFR1) polymorphism between ankylosing spondylitis (AS) and controls. Mexican Mestizos with AS were matched by gender, age, and ethnicity with healthy controls and compared in allele and genotype frequencies of the -383 TNFR1 polymorphism. Polymorphisms were genotyped using PCR-RFLP. The AA genotype occurred at a higher frequency in the AS group (92%) compared with controls (79%, P = 0.03). A allele was increased in AS (96% vs. 88%, P = 0.015) and was associated with genetic susceptibility for AS (odds ratio = 3.48, 95% CI = 1.23-10.61). This preliminary study is the first assessing the association of the -383 A/C TNFR1 polymorphism with AS, although it has the limitation of a small sample size. These data are of interest for the genetic epidemiology of AS in the Mexican population, requiring further investigation in other countries.

引用

页码：2565 / 2568

页数：4

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