Chemical approaches to studying stem cell biology

被引：26

作者：

Li, Wenlin ^{[2
]}

Jiang, Kai ^{[1
]}

Wei, Wanguo ^{[3
]}

Shi, Yan ^{[4
]}

Ding, Sheng ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Second Mil Med Univ, Dept Cell Biol, Shanghai 200433, Peoples R China

[3] Chinese Acad Sci, Stem Cell & Regenerat Med Ctr, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China

[4] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen 518055, Guangdong, Peoples R China

来源：

CELL RESEARCH | 2013年 / 23卷 / 01期

关键词：

small molecules; stem cells; self-renewal; differentiation; SMALL-MOLECULE; SELF-RENEWAL; DIRECTED DIFFERENTIATION; HUMAN FIBROBLASTS; ENDOCRINE-CELLS; GENERATION; INDUCTION; MOUSE; SPECIFICATION; PROMOTES;

D O I：

10.1038/cr.2012.182

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipulate stem cell fates is essential to understand the basic mechanisms of stem cell biology, and to translate stem cells into regenerative medicine. Chemical approaches have recently provided a number of small molecules that can be used to control cell self-renewal, lineage differentiation, reprogramming and regeneration. These chemical modulators have been proven to be versatile tools for probing stem cell biology and manipulating cell fates toward desired outcomes. Ultimately, this strategy is promising to be a new frontier for drug development aimed at endogenous stem cell modulation.

引用

页码：81 / 91

页数：11

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