Morphea and other localized forms of scleroderma

被引:17
作者
Vasquez, Rebecca [1 ]
Sendejo, Chelsea [2 ]
Jacobe, Heidi [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Dermatol, Dallas, TX 75390 USA
[2] Univ Texas Pan Amer, Edinburg, TX 78541 USA
关键词
localized scleroderma; morphea; outcome measures; treatment; SYSTEMIC-SCLEROSIS; CLINICAL-FEATURES; SINGLE-CENTER; DOUBLE-BLIND; SKIN; CHILDHOOD; CHILDREN; DISEASE; AUTOANTIBODIES; INTERLEUKIN-13;
D O I
10.1097/BOR.0b013e32835896ce
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Morphea, also known as localized scleroderma, is a disorder of excessive collagen deposition leading to thickening of the dermis and/or subcutaneous tissues and may cause significant morbidity. This review will describe new developments in the evaluation and management of morphea as well as its pathophysiology. The reader will be able to apply these findings to patient management. Recent findings The recent development of validated outcome measures (i.e. the localized scleroderma cutaneous assessment tool) as well as consensus treatment recommendations provide a platform for collaboration among specialties to develop both standardized assessment tools and therapeutic trials. New studies have also begun to investigate the immunological underpinnings of morphea. Summary The promise of evidence-based treatments for morphea in the near future will provide better care for patients with morphea and understanding its pathophysiology will lay groundwork for the development of new treatments.
引用
收藏
页码:685 / 693
页数:9
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