Morphea and other localized forms of scleroderma

被引:17
|
作者
Vasquez, Rebecca [1 ]
Sendejo, Chelsea [2 ]
Jacobe, Heidi [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Dermatol, Dallas, TX 75390 USA
[2] Univ Texas Pan Amer, Edinburg, TX 78541 USA
关键词
localized scleroderma; morphea; outcome measures; treatment; SYSTEMIC-SCLEROSIS; CLINICAL-FEATURES; SINGLE-CENTER; DOUBLE-BLIND; SKIN; CHILDHOOD; CHILDREN; DISEASE; AUTOANTIBODIES; INTERLEUKIN-13;
D O I
10.1097/BOR.0b013e32835896ce
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Morphea, also known as localized scleroderma, is a disorder of excessive collagen deposition leading to thickening of the dermis and/or subcutaneous tissues and may cause significant morbidity. This review will describe new developments in the evaluation and management of morphea as well as its pathophysiology. The reader will be able to apply these findings to patient management. Recent findings The recent development of validated outcome measures (i.e. the localized scleroderma cutaneous assessment tool) as well as consensus treatment recommendations provide a platform for collaboration among specialties to develop both standardized assessment tools and therapeutic trials. New studies have also begun to investigate the immunological underpinnings of morphea. Summary The promise of evidence-based treatments for morphea in the near future will provide better care for patients with morphea and understanding its pathophysiology will lay groundwork for the development of new treatments.
引用
收藏
页码:685 / 693
页数:9
相关论文
共 50 条
  • [11] A CASE OF LOCALIZED SCLERODERMA (MORPHEA) IN A DOG
    BOURDEAU, P
    DEGORCE, F
    FOURRIER, P
    RECUEIL DE MEDECINE VETERINAIRE, 1991, 167 (12) : 1121 - 1125
  • [12] MRI findings in deep and generalized morphea (localized scleroderma)
    Horger, Marius
    Fierlbeck, Gerhard
    Kuemmerle-Deschner, Jasmin
    Tzaribachev, Nikolay
    Wehrmann, Manfred
    Claussen, Claus D.
    Fritz, Jan
    AMERICAN JOURNAL OF ROENTGENOLOGY, 2008, 190 (01) : 32 - 39
  • [13] Choroidal sclerosis in localized scleroderma (Morphea en plaque)
    Milenkovic, S.
    Petrovic, L.
    Risimic, D.
    Kosanovic-Jakovic, N.
    Jaksic, V.
    Djakovic, Z.
    Stojkovic, M.
    Risovic, D.
    Ivankovic, Lj.
    Ivancevic-Milenkovic, M.
    OPHTHALMIC RESEARCH, 2008, 40 (02) : 101 - 104
  • [14] Pediatric Morphea (Localized Scleroderma)-Epidemiological, Clinical and Laboratory Findings of 14 Cases
    Izol, Belcin
    Saricaoglu, Hayriye
    Baskan, Emel Bulbul
    Toka, Sevil Ovali
    Adim, Saduman Balaban
    Aydogan, Kenan
    Tunali, Sukran
    TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, 2011, 45 (03): : 132 - 136
  • [15] Diagnosis and Therapy of Localized Scleroderma
    Kreuter, Alexander
    Krieg, Thomas
    Worm, Margitta
    Wenzel, Joerg
    Gambichler, Thilo
    Kuhn, Annegret
    Aberer, Elisabeth
    Scharffetter-Kochanek, Karin
    Hunzelmann, Nicolas
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2009, 7 : S1 - S12
  • [16] Treatment of Morphea or Localized Scleroderma: Review of the Literature
    Santos Vilela, Fernanda Aguiar
    Carneiro, Sueli
    Ramos-E-Silva, Marcia
    JOURNAL OF DRUGS IN DERMATOLOGY, 2010, 9 (10) : 1213 - 1219
  • [17] Localized scleroderma
    Al-Gburi, Suzan
    Kreuter, Alexander
    Moinzadeh, Pia
    DERMATOLOGIE, 2024, 75 (03): : 197 - 207
  • [18] Localized scleroderma
    Kreuter, Alexander
    DERMATOLOGIC THERAPY, 2012, 25 (02) : 135 - 147
  • [19] United Kingdom survey of current management of juvenile localized scleroderma
    Hawley, Daniel P.
    Pain, Clare E.
    Baildam, Eileen M.
    Murphy, Ruth
    Taylor, Aileen E. M.
    Foster, Helen E.
    RHEUMATOLOGY, 2014, 53 (10) : 1849 - 1854
  • [20] Unilateral generalized morphea is a rare variant of localized scleroderma
    Appelhans, C.
    Breuckmann, F.
    Gambichler, T.
    Brockmeyer, N. H.
    Altmeyer, P.
    Kreuter, A.
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2006, 11 (04) : 152 - 156