Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma

被引：44
作者：
Jin, Jingchun [1 ,4 ]
Jin, Tiefeng [1 ,2 ]
Quan, Meiling [1 ,2 ]
Piao, Yingshi [2 ,3 ]
Lin, Zhenhua [1 ,2 ]
机构：
[1] Yanbian Univ Med Coll, Dept Pathol, Yanji 133002, Jilin Prov, Peoples R China
[2] Yanbian Univ, Canc Res Ctr, Yanji 133002, Jilin Prov, Peoples R China
[3] Yanbian Univ Med Coll, Dept Pathophysiol, Yanji 133002, Jilin Prov, Peoples R China
[4] Yanbian Univ Affiliated Hosp, Dept Internal Med, Yanji 133000, Jilin Prov, Peoples R China
来源：
DIAGNOSTIC PATHOLOGY | 2012年 / 7卷
基金：
中国国家自然科学基金;
关键词：
Gastric adenocarcinoma; Ezrin; Tissue microarray; ERM PROTEINS; CANCER CELLS; EXPRESSION; METASTASIS; INVASION; CARCINOMAS; PHOSPHORYLATION; MIGRATION; MERLIN;
D O I：
10.1186/1746-1596-7-135
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Background: Ezrin is a cytoskeletal protein that is involved in tumor growth and invasion. It has been suggested that Ezrin expression plays an important role in tumor metastasis. This study is aimed to investigate the clinicopathological significance of Ezrin overexpression in gastric adenocarcinomas. Methods: Ezrin protein expression was examined by immunohistochemistry in 26 normal gastric mucosa, 32 dysplasia, and 277 gastric adenocarcinomas. The relationship between Ezrin expression and the clinicopathological features of gastric cancers was analyzed. In addition, a gastric cancer cell line, MKN-1, was also used for immunofluorescence staining to evaluate the distribution of Ezrin protein. Results: Ezrin protein located in the cytoplasm and/or membrane in the migrating gastric cancer cells, and it mainly concentrated at the protrusion site; however, only cytoplasmic distribution was observed in the non-migrating cancer cells by immunofluorescence staining. The positive rate of Ezrin protein expression was significantly higher in gastric adenocarcinoma and dysplasia compared with that in the normal gastric mucosa. Moreover, expression frequency of Ezrin protein increased significantly in lymph node metastasis and late clinical stages. Consistently, strong expression of Ezrin was significantly correlated with poor prognosis of gastric cancer. Conclusion: The detection of Ezrin expression can be used as the marker for early diagnosis and prognosis of gastric adenocarcinoma.
引用
收藏
页数：8
相关论文
共 32 条
[1]  
[Anonymous], 2002, AJCC CANC STAGING MA, VSixth
[2]  
Bal N, 2007, WORLD J GASTROENTERO, V13, P3726
[3]  
BERRYMAN M, 1993, J CELL SCI, V105, P1025
[4]  
Brenner Hermann, 2009, V472, P467, DOI 10.1007/978-1-60327-492-0_23
[5]   ERM proteins and merlin: Integrators at the cell cortex [J].
Bretscher, A ;
Edwards, K ;
Fehon, RG .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (08) :586-599
[6]   The Ezrin Metastatic Phenotype Is Associated with the Initiation of Protein Translation [J].
Briggs, Joseph W. ;
Ren, Ling ;
Nguyen, Rachel ;
Chakrabarti, Kristi ;
Cassavaugh, Jessica ;
Rahim, Said ;
Bulut, Gulay ;
Zhou, Ming ;
Veenstra, Timothy D. ;
Chen, Qingrong ;
Wei, Jun S. ;
Khan, Javed ;
Uren, Aykut ;
Khanna, Chand .
NEOPLASIA, 2012, 14 (04) :297-+
[7]   Gastric cancer [J].
Catalano, Vincenzo ;
Labianca, Roberto ;
Beretta, Giordano D. ;
Gatta, Gemma ;
De Braud, Filippo ;
Van Cutsem, Eric .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2009, 71 (02) :127-164
[8]   Rho Kinase Phosphorylation Promotes Ezrin-Mediated Metastasis in Hepatocellular Carcinoma [J].
Chen, Yong ;
Wang, Dongmei ;
Guo, Zhen ;
Zhao, Jun ;
Wu, Bing ;
Deng, Hui ;
Zhou, Ti ;
Xiang, Hongjun ;
Gao, Fei ;
Yu, Xue ;
Liao, Jian ;
Ward, Tarsha ;
Xia, Peng ;
Emenari, Chibuzo ;
Ding, Xia ;
Thompson, Winston ;
Ma, Kelong ;
Zhu, Jingde ;
Aikhionbare, Felix ;
Dou, Kefen ;
Cheng, Shi-Yuan ;
Yao, Xuebiao .
CANCER RESEARCH, 2011, 71 (05) :1721-1729
[9]   Expression of Plakophilins (PKP1, PKP2, and PKP3) in Gastric Cancers [J].
Demirag, Guzin G. ;
Sullu, Yurdanur ;
Gurgenyatagi, Dilek ;
Okumus, Nilgun O. ;
Yucel, Idris .
DIAGNOSTIC PATHOLOGY, 2011, 6
[10]   E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome [J].
Elzagheid, Adam ;
Algars, Annika ;
Bendardaf, Riyad ;
Lamlum, Hanan ;
Ristamaki, Raija ;
Collan, Yrjo ;
Syrjanen, Kari ;
Pyrhonen, Seppo .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (27) :4304-4309
1234