A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity

被引：20

作者：

Yang, Chung-Ping ^{[2
]}

Huang, Guan-Jhong ^{[2
]}

Huang, Hui-Chi ^{[2
]}

Chen, Yu-Chang ^{[2
]}

Chang, Chi-I ^{[3
]}

Wang, Sheng-Yang ^{[4
,5
]}

Chen, Ih-Sheng ^{[6
]}

Tseng, Yen-Hsueh ^{[4
]}

Chien, Shih-Chang ^{[1
]}

Kuo, Yueh-Hsiung ^{[2
,7
]}

机构：

[1] Natl Chung Hsing Univ, Expt Forest Management Off, Taichung 402, Taiwan

[2] China Med Univ, Sch Chinese Pharmaceut Sci & Chinese Med Resource, Taichung 404, Taiwan

[3] Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung 912, Taiwan

[4] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan

[5] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan

[6] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[7] China Med Univ, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan

来源：

MOLECULES | 2012年 / 17卷 / 06期

关键词：

Chinese medicinal herbs; Lindera akoensis; butanolide; anti-inflammatory; NITRIC-OXIDE; ROOT; CONSTITUENTS; ALKALOIDS;

D O I：

10.3390/molecules17066585

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new butanolide, 3 beta-((E)-dodec-1-enyl)-4 beta-hydroxy-5 beta-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4 alpha,5 beta)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4 alpha,5 beta)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC50 values of 1.4-179.9 mu M.

引用

页码：6585 / 6592

页数：8

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