Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B

被引:55
|
作者
Matsumoto, Akihiro
Tanaka, Eiji [1 ]
Suzuki, Yoshiyuki [2 ]
Kobayashi, Mariko [2 ]
Tanaka, Yasuhito [4 ,5 ]
Shinkai, Noboru [4 ,5 ]
Hige, Shuhei [7 ]
Yatsuhashi, Hiroshi [9 ]
Nagaoka, Shinya [9 ]
Chayama, Kazuaki [10 ]
Tsuge, Masataka [10 ]
Yokosuka, Osamu [11 ]
Imazeki, Fumio [11 ]
Nishiguchi, Shuhei [12 ]
Saito, Masaki [12 ]
Fujiwara, Kei [6 ]
Torii, Nobuyuki [3 ]
Hiramatsu, Naoki [13 ]
Karino, Yoshiyasu [8 ]
Kumada, Hiromitsu [2 ]
机构
[1] Shinshu Univ, Sch Med, Dept Med, Div Gastroenterol, Matsumoto, Nagano 3908621, Japan
[2] Toranomon Gen Hosp, Dept Hepatol, Tokyo, Japan
[3] Tokyo Womens Med Univ, Dept Internal Med & Gastroenterol, Tokyo, Japan
[4] Nagoya City Univ, Grad Sch Med Sci, Dept Virol, Nagoya, Aichi, Japan
[5] Nagoya City Univ, Grad Sch Med Sci, Liver Unit, Nagoya, Aichi, Japan
[6] Nagoya Daini Red Cross Hosp, Gastroenterol Sect, Nagoya, Aichi, Japan
[7] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sapporo, Hokkaido, Japan
[8] Sapporo Kosei Gen Hosp, Dept Gastroenterol, Sapporo, Hokkaido, Japan
[9] NHO Nagasaki Med Ctr, Clin Res Ctr, Omura, Japan
[10] Hiroshima Univ, Grad Sch Biomed Sci, Program Biomed Res, Div Frontier Med Sci,Dept Med & Mol Sci, Hiroshima, Japan
[11] Chiba Univ, Grad Sch Med, Dept Med & Clin Oncol, Chiba, Japan
[12] Hyogo Coll Med, Dept Internal Med, Div Hepatobiliary & Pancreat Dis, Nishinomiya, Hyogo, Japan
[13] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Osaka, Japan
关键词
discontinuation; hepatitis B core-related antigen; hepatitis B surface antigen; nucleos(t)ide analogs; relapse of hepatitis; CORE-RELATED ANTIGEN; CLOSED CIRCULAR DNA; HEPATOCELLULAR-CARCINOMA; SUSTAINED RESPONSE; VIRUS INFECTION; LAMIVUDINE; MANAGEMENT; ENTECAVIR; CESSATION; HBV;
D O I
10.1111/j.1872-034X.2011.00910.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Aim: The factors associated with hepatitis recurrence after discontinuation of nucleos(t)ide analogs (NAs) in patients with chronic hepatitis B were analyzed to predict the risk of relapse more accurately.
引用
收藏
页码:139 / 149
页数:11
相关论文
共 50 条
  • [1] Improving the Prediction of Relapse After Nucleos(t)ide Analogue Discontinuation in Patients With Chronic Hepatitis B
    Song, Do Seon
    Jang, Jeong Won
    Yoo, Sun Hong
    Kwon, Jung Hyun
    Nam, Soon Woo
    Bae, Si Hyun
    Choi, Jong Young
    Yoon, Seung Kew
    CLINICAL INFECTIOUS DISEASES, 2021, 73 (04) : E892 - E903
  • [2] Relapse of Chronic Hepatitis B After Discontinuation of Nucleos(t)ide Analogs: Is the Glass Half Full or Half Empty?
    Reijnders, Jurrien G. P.
    Janssen, Harry L. A.
    HEPATOLOGY, 2013, 58 (06) : 1885 - 1887
  • [3] Combinational use of hepatitis B viral antigens predicts responses to nucleos(t)ide analogue/peg-interferon sequential therapy
    Matsumoto, Akihiro
    Nishiguchi, Shuhei
    Enomoto, Hirayuki
    Kang, Jong-Hon
    Tanaka, Yasuhito
    Shinkai, Noboru
    Kurosaki, Masayuki
    Enomoto, Masaru
    Kanda, Tatsuo
    Yokosuka, Osamu
    Yatsuhashi, Hiroshi
    Nagaoka, Shinya
    Okuse, Chiaki
    Kagawa, Tatehiro
    Mine, Tetsuya
    Takaguchi, Koichi
    Saito, Satoru
    Hino, Keisuke
    Ikeda, Fusao
    Sakisaka, Shotaro
    Morihara, Daisuke
    Miyase, Shiho
    Tsuge, Masataka
    Chayama, Kazuaki
    Hiramatsu, Naoki
    Suzuki, Yoshiyuki
    Murata, Kazumoto
    Tanaka, Eiji
    JOURNAL OF GASTROENTEROLOGY, 2018, 53 (02) : 247 - 257
  • [4] The Baseline and On treatment Predictive Factors of Hepatitis B Relapse after Nucleos(t)ide Analogue Discontinuation in Chronic Hepatitis B: A Prospective study
    Kaewdech, Apichat
    Sripongpun, Pimsiri
    Jundee, Sawangpong
    Chamroonkul, Naichaya
    Piratvisuth, Teerha
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 34 : 236 - 236
  • [5] Biomarkers for predicting nucleos(t)ide analogs discontinuation and hepatitis B virus recurrence after drug withdrawal in chronic hepatitis B patients
    Luo, Mengqi
    Zhou, Bin
    Hou, Jinlin
    Jiang, Deke
    HEPATOLOGY RESEARCH, 2022, 52 (04) : 337 - 351
  • [6] Serum Pregenomic RNA Combined With Hepatitis B Core-Related Antigen Helps Predict the Risk of Virological Relapse After Discontinuation of Nucleos(t)ide Analogs in Patients With Chronic Hepatitis B
    Wang, Fa-Da
    Zhou, Jing
    Li, Lan-Qing
    Wang, Meng-Lan
    Tao, Ya-Cao
    Wang, Yong-Hong
    Zhang, Dong-Mei
    Chen, En-Qiang
    FRONTIERS IN MICROBIOLOGY, 2022, 13
  • [7] Off-Treatment Hepatitis B Virus (HBV) DNA Levels and the Prediction of Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B: A Prospective Stop Study
    Cao, Jiawei
    Chi, Heng
    Yu, Tao
    Li, Zhandong
    Hansen, Bettina E.
    Zhang, Xiaoyong
    Zhong, Chunxiu
    Sun, Jian
    Hou, Jinlin
    Janssen, Harry L. A.
    Peng, Jie
    JOURNAL OF INFECTIOUS DISEASES, 2017, 215 (04) : 581 - 589
  • [8] Hepatitis B surface antigen levels of cessation of nucleos(t)ide analogs associated with virological relapse in hepatitis B surface antigen-negative chronic hepatitis B patients
    Ge, Guo-Hong
    Ye, Yun
    Zhou, Xin-Bei
    Chen, Li
    He, Cong
    Wen, Dan-Feng
    Tan, You-Wen
    WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (28) : 8653 - 8659
  • [9] Monitoring and comorbidities in patients with chronic hepatitis B currently treated with nucleos(t)ide analogs
    Siakavellas, Spyros
    Goulis, John
    Manolakopoulos, Spilios
    Triantos, Christos
    Gatselis, Nikolaos
    Tsentemidou, Eva
    Kranidioti, Hariklia
    Zisimopoulos, Konstantinos
    Tsoulas, Christos
    Dalekos, George
    Papatheodoridis, George
    ANNALS OF GASTROENTEROLOGY, 2021, 34 (01): : 73 - 79
  • [10] Residual Amount of HBV DNA in Serum is Related to Relapse in Chronic Hepatitis B Patients After Cessation of Nucleos(t)ide Analogs
    Jiang, Jian-ning
    Huang, Zhan-lian
    He, Li-xia
    Huang, Yue-hua
    Su, Ming-hua
    Xie, Rong
    Liang, Yan-xiu
    Fu, Wu-dao
    Huang, Xiao-hong
    Guo, Wen-wen
    Zhong, Shao-hua
    Liu, Zhi-hong
    Li, Shi-hua
    Zhu, Tuo-fu
    Gao, Zhi-liang
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2015, 49 (04) : 323 - 328