Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels

被引:74
作者
Richardson, JR
Miller, GW
机构
[1] Emory Univ, Ctr Neurodegenerat Dis, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
[2] Emory Univ, Dept Environm & Occupat Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
关键词
polychlorinated biphenyl; dopamine; dopamine transporter; vesicular monoamine transporter; Aroclor; 1016; 1260;
D O I
10.1016/j.toxlet.2003.12.006
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Polychlorinated biphenyls (PCBs) have been shown to specifically target the dopaminergic nervous system, resulting in long-term reduction of striatal dopamine (DA) levels. However, the mechanism(s) by which PCBs exert this effect is not known. Here we report that decreased striatal dopamine levels are observed 1, 7, and 14 days after acute exposure to the common PCB mixtures Aroclor 1016 or 1260. Dopamine transporter (DAT) levels were decreased at all time points in Aroclor 1016 treated animals, and on Days I and 7 in Aroclor 1260 treated animals. Vesicular monoamine transporter 2 (VMAT2) levels were not affected by Aroclor 1016, but were significantly decreased 14 days after exposure to Aroclor 1260. Tyrosine hydroxylase expression, a marker of dopamine neuron integrity, was not significantly affected by PCB exposure at any time. These data suggest that PCB-induced reductions in striatal dopamine may be mediated by alterations in DAT and VMAT2 expression. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:29 / 40
页数:12
相关论文
共 32 条
[1]   NEUROTRANSMITTER TRANSPORTERS - RECENT PROGRESS [J].
AMARA, SG ;
KUHAR, MJ .
ANNUAL REVIEW OF NEUROSCIENCE, 1993, 16 :73-93
[2]   Effects of polychlorinated biphenyls on dopamine release from PC12 cells [J].
Angus, WGR ;
Contreras, ML .
TOXICOLOGY LETTERS, 1996, 89 (03) :191-199
[3]  
Angus WGR, 1997, NEUROTOXICOLOGY, V18, P857
[4]  
*ATSDR, 2000, TOX PROF POL BIPH, P43
[5]  
Chishti MA, 1996, NEUROTOXICOLOGY, V17, P653
[6]  
ERICKSON MD, 1986, ANAL CHEM PCBS
[7]   Effects of polychlorinated biphenyls on the nervous system [J].
Faroon, O ;
Jones, D ;
De Rosa, C .
TOXICOLOGY AND INDUSTRIAL HEALTH, 2000, 16 (7-8) :307-333
[8]   Impact of psycho stimulants on vesicular monoamine transporter function [J].
Fleckenstein, AE ;
Hanson, GR .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 479 (1-3) :283-289
[9]   Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action [J].
Fon, EA ;
Pothos, EN ;
Sun, BC ;
Killeen, N ;
Sulzer, D ;
Edwards, RH .
NEURON, 1997, 19 (06) :1271-1283
[10]  
Fumagalli F, 1999, J NEUROSCI, V19, P2424