Phosphate transporters of the SLC20 and SLC34 families

被引：171

作者：

Forster, Ian C. ^{[1
]}

Hernando, Nati

Biber, Juerg

Murer, Heini

机构：

[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

来源：

MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 2-3期

基金：

瑞士国家科学基金会;

关键词：

SLC20; SLC34; Phosphate; Cotransport; P-I COTRANSPORTER; APE LEUKEMIA-VIRUS; HEREDITARY HYPOPHOSPHATEMIC RICKETS; DEPENDENT PHOSPHATE; INORGANIC-PHOSPHATE; MOLECULAR DETERMINANTS; HORMONAL-REGULATION; CELLULAR RECEPTOR; APICAL EXPRESSION; PIT-2; SLC20A2;

D O I：

10.1016/j.mam.2012.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transport of inorganic phosphate (Pi) across the plasma membrane is essential for normal cellular function. Members of two families of SLC proteins (SLC20 and SLC34) act as Na+ dependent, secondary-active cotransporters to transport P-i across cell membranes. The SLC34 proteins are expressed in specific organs important for P-i homeostasis: NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) fulfill essential roles in P-i reabsorption in the kidney proximal tubule and NaPi-IIb (SLC34A2) mediates P-i absorption in the gut. The SLC20 proteins, PiT-1 (SLC20A1), PiT-2 (SLC20A2) are expressed ubiquitously in all tissues and although generally considered as "housekeeping" transport proteins, the discovery of tissue-specific activity, regulatory pathways and gene-related pathophysiologies, is redefining their importance. This review summarizes our current knowledge of SLC20 and SLC34 proteins in terms of their basic molecular characteristics, physiological roles, known pathophysiology and pharmacology. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：386 / 395

页数：10

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