Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media

被引：10
|
作者：
Kumar, Anand T. N. [1 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp,Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
来源：
OPTICS LETTERS | 2012年 / 37卷 / 22期
基金：
美国国家卫生研究院;
关键词：
PHOTON MIGRATION; TISSUES; TOMOGRAPHY; SIMULATION;
D O I：
10.1364/OL.37.004783
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We show that a multiexponential model for time-resolved fluorescence allows the use of an absorption-perturbation Monte Carlo (MC) approach based on stored photon path histories. This enables the rapid fitting of fluorescence yield, lifetimes, and background tissue absorptions in complex heterogeneous media within a few seconds, without the need for temporal convolutions or MC recalculation of photon path lengths. We validate this method using simulations with both a slab and a heterogeneous model of the mouse head. (C) 2012 Optical Society of America
引用
收藏
页码：4783 / 4785
页数：3
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