Correlation between volume and morphological changes in the hippocampal formation in Alzheimer's disease: rounding of the outline of the hippocampal body on coronal MR images

被引：4

作者：

Adachi, Michito ^{[1
]}

Kawakatsu, Shinobu ^{[2
]}

Sato, Takamichi ^{[1
]}

Ohshima, Fumi ^{[3
]}

机构：

[1] Ohshima Clin, Dept Radiol, Yamagata 9902321, Japan

[2] Yamagata Univ, Dept Psychiat, Sch Med, Yamagata 9909585, Japan

[3] Ohshima Clin, Dept Neurol, Yamagata 9902321, Japan

来源：

NEURORADIOLOGY | 2012年 / 54卷 / 10期

关键词：

Magnetic resonance imaging; Brain; Alzheimer's disease; Hippocampus; VOXEL-BASED MORPHOMETRY; ENTORHINAL CORTEX; DIAGNOSIS; ATROPHY; IMPAIRMENT; PATHOLOGY; SEVERITY; DEMENTIA; DURATION; CA1;

D O I：

10.1007/s00234-012-1019-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to investigate whether the outline of the hippocampal body becomes rounded on coronal magnetic resonance imaging (MRI) as the volume of the hippocampal formation decreases in Alzheimer's disease (AD). Institutional review board approval of the study protocol was obtained, and all subjects provided informed consent for the mini-mental state examination (MMSE) and MRI. The MRI and MMSE were prospectively performed in all 103 subjects (27 men and 76 women; mean age +/- standard deviation, 77.7 +/- 7.8 years) who had AD or were concerned about having of dementia and who consulted our institute over 1 year. The subjects included 14 non-dementia cases (MMSE score a parts per thousand yenaEuro parts per thousand 28) and 89 AD cases (MMSE score a parts per thousand currency signaEuro parts per thousand 27). The total volume of the bilateral hippocampal formation (VHF) was assessed with a tracing method, and the ratio of the VHF to the intracranial volume (RVHF) and the rounding ratio (RR) of the hippocampal body (mean ratio of its short dimension to the long dimension in the bilateral hippocampal body) were calculated. Using Spearman's correlation coefficient, the correlations between RR and VHF and between RR and RVHF were assessed. Correlation coefficients between RR and VHF and between RR and RVHF were -0.419 (p < 0.01) and -0.418 (p < 0.01), respectively. There was a significant negative correlation between RR and the volume of the hippocampal formation. The outline of the body of the hippocampal formation becomes rounded on coronal images as its volume decreases in AD.

引用

页码：1079 / 1087

页数：9

共 30 条

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