Antiproliferative activity of aucubin is through cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells

被引：50

作者：

Hung, Jen-Yu ^{[1
]}

Yang, Chih-Jen ^{[1
]}

Tsai, Ying-Ming ^{[1
]}

Huang, Hurng-Wern ^{[2
]}

Huang, Ming-Shyan ^{[1
,3
]}

机构：

[1] Kaohsiung Med Univ Hosp, Div Pulm & Crit Care Med, Kaohsiung 807, Taiwan

[2] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 80424, Taiwan

[3] Kaohsiung Med Univ Joint Res Ctr, Natl Sun Yat Sen Univ, Kaohsiung, Taiwan

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2008年 / 35卷 / 09期

关键词：

apoptosis; aucubin; cell cycle; Fas ligand; Fas; p53;

D O I：

10.1111/j.1440-1681.2008.04935.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Aucubin, an iridoid glycoside isolated from the leaves of Aucuba japonica, inhibits human non-small cell lung cancer A549 cells by blocking cell cycle progression in the G(0)/G(1) phase and inducing apoptosis. 2. An ELISA showed that the G(0)/G(1) phase arrest is due to p53-mediated induction of p21. Enhancement of Fas and its two ligands, membrane-bound and soluble Fas ligand, may be responsible for the apoptotic effect induced by aucubin. 3. The present study shows, for the first time, that the induction of p53 and activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of aucubin in A549 cells.

引用

页码：995 / 1001

页数：7

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