Guanidinoacetic Acid and Creatine are Associated with Cardiometabolic Risk Factors in Healthy Men and Women: A Cross-Sectional Study

被引：14

作者：

Ostojic, Sergej M. ^{[1
,2
]}

Vranes, Milan ^{[3
]}

Loncar, Davor ^{[4
]}

Zenic, Natasa ^{[5
]}

Sekulic, Damir ^{[5
]}

机构：

[1] Univ Novi Sad, Fac Sport & Phys Educ, Novi Sad 21000, Serbia

[2] Univ Belgrade, Sch Med, Belgrade 21000, Serbia

[3] Univ Novi Sad, Fac Sci, Novi Sad 21000, Serbia

[4] Inst SUPERLAB, Belgrade 11000, Serbia

[5] Univ Split, Fac Kinesiol, Split 21000, Croatia

来源：

NUTRIENTS | 2018年 / 10卷 / 01期

关键词：

guanidinoacetic acid; creatine; cardiometabolic risk; homocysteine; overweight; BODY-MASS INDEX; SERUM CREATININE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; BLOOD-PRESSURE; KINASE; SUPPLEMENTATION; DETERMINANTS; HYPERTENSION; HOMOCYSTEINE;

D O I：

10.3390/nu10010087

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Guanidinoacetic acid (GAA) conversion to creatine is thought to be involved in cardiometabolic disturbances through its role in biological methylation and insulin secretion. We evaluated the association of serum GAA and creatine with cardiometabolic risk factors in a cohort of 151 apparently healthy adults (82 women and 69 men) aged 18-63 years. Serum levels of GAA and creatine were measured with liquid chromatography-tandem mass spectrometry. A multiple linear regression model adjusted for age and sex was employed to examine the relationship of serum GAA and creatine with cardiometabolic risk factors. Higher GAA levels were associated with an unfavorable cardiometabolic risk profile (higher insulin, higher total homocysteine, and higher body fat percentage), while having elevated serum creatine levels (31.1 mu mol/L) was associated with being overweight (body mass index 25.0 kg/m). The results from our study suggest a possible role of the GAA-creatine axis in the pathogenesis of cardiovascular and metabolic diseases.

引用

页数：8

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