Blue rubber bleb nevus syndrome associated with consumption coagulopathy:: treatment with interferon

被引：31

作者：

Apak, H

Celkan, T

Özkan, A

Yildiz, I

Aydemir, EH

Ozdil, S

Kuruoglu, S

机构：

[1] Cerrahpasa Med Sch, Pediat Hematol Oncol Dept, Istanbul, Turkey

[2] Cerrahpasa Med Sch, Dept Pediat Radiol, Istanbul, Turkey

[3] Istanbul Univ, Dept Dermatol, Istanbul Med Sch, Istanbul, Turkey

[4] Istanbul Univ, Dept Gastroenterol, Istanbul Med Sch, Istanbul, Turkey

来源：

DERMATOLOGY | 2004年 / 208卷 / 04期

关键词：

blue rubber bleb nevus syndrome; bean syndrome; disseminated intravascular coagulation; interferon;

D O I：

10.1159/000077846

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The blue rubber bleb nevus syndrome (BRBNS) is a rare vascular malformation syndrome with cutaneous and visceral lesions frequently associated with serious, even fatal bleeding. No systemic therapy is currently available. We report here a case with disseminated skin and gastrointestinal venous malformations and findings of disseminated intravascular coagulation that was treated with interferon beta. The disseminated intravascular coagulation manifestations were cleared with the treatment. The regression of the coagulopathy in our patient led us to think that the use of interferon beta in BRBNS might be beneficial. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：345 / 348

页数：4

共 21 条

[1] Blue rubber bleb nevus syndrome: Endoscopic removal of the gastrointestinal hemangiomas [J].

Bak, YT ;

Oh, CH ;

Kim, JH ;

Lee, CH .

GASTROINTESTINAL ENDOSCOPY, 1997, 45 (01) :90-92

[2]

Bean WB., 1958, Vascular Spiders and Related Lesions of the Skin, P178

[3]

BERLYNE GM, 1960, LANCET, V2, P1275

[4] Blue rubber bleb nevus (Bean syndrome): Evolution of four cases and clinical response to pharmacologic agents [J].

Boente, MD ;

Cordisco, MR ;

Frontini, MD ;

Asial, RA .

PEDIATRIC DERMATOLOGY, 1999, 16 (03) :222-227

[5] Bilateral multifocal hemangiomas of the orbit in the blue rubber bleb nevus syndrome [J].

Chang, EL ;

Rubin, PAD .

OPHTHALMOLOGY, 2002, 109 (03) :537-541

[6] Vascular tumors and vascular malformations: Are we at the dawn of a better knowledge? [J].

Enjolras, O .

PEDIATRIC DERMATOLOGY, 1999, 16 (03) :238-241

[7] BLUE RUBBER BLEB NEVUS SYNDROME - GASTROINTESTINAL INVOLVEMENT AND ITS ENDOSCOPIC PRESENTATION [J].

GALLO, SH ;

MCCLAVE, SA .

GASTROINTESTINAL ENDOSCOPY, 1992, 38 (01) :72-76

[8] A prospective study of cutaneous adverse events induced by low-dose alpha-interferon treatment for malignant melanoma [J].

Guillot, B ;

Blazquez, L ;

Bessis, D ;

Dereure, O ;

Guilhou, JJ .

DERMATOLOGY, 2004, 208 (01) :49-54

[9] BLUE RUBBER-BLEB NEVUS SYNDROME - REPORT OF A CASE WITH CONSUMPTION COAGULOPATHY COMPLICATED BY MANIFEST THROMBOSIS [J].

HOFHUIS, WJD ;

ORANJE, AP ;

BOUQUET, J ;

SINAASAPPEL, M .

EUROPEAN JOURNAL OF PEDIATRICS, 1990, 149 (08) :526-528

[10] Blue rubber bleb nevus syndrome with central nervous system involvement [J].

Kim, SJ .

PEDIATRIC NEUROLOGY, 2000, 22 (05) :410-412

← 1 2 3 →