Short leukocyte telomere length is associated with obesity in American Indians: The strong heart family study

被引：60
作者：
Chen, Shufeng [1 ,2 ,3 ,4 ,5 ]
Yeh, Fawn [6 ]
Lin, Jue [7 ]
Matsuguchi, Tet [7 ]
Blackburn, Elizabeth [7 ]
Lee, Elisa T. [6 ]
Howard, Barbara V. [8 ,9 ]
Zhao, Jinying [1 ]
机构：
[1] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA
[2] Chinese Acad Med Sci, Cardiovasc Inst, Dept Evidence Based Med, Beijing 100730, Peoples R China
[3] Chinese Acad Med Sci, Cardiovasc Inst, Div Populat Genet, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China
[4] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing 100730, Peoples R China
[5] Peking Union Med Coll, Beijing 100021, Peoples R China
[6] Univ Oklahoma, Hlth Sci Ctr, Ctr Amer Indian Hlth Res, Oklahoma City, OK 73104 USA
[7] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
[8] MedStar Hlth Res Inst, Hyattsville, MD 20782 USA
[9] Georgetown Univ, Howard Univ, Ctr Clin & Translat Sci, Washington, DC 20007 USA
来源：
AGING-US | 2014年 / 6卷 / 05期
基金：
美国国家卫生研究院;
关键词：
obesity; Leukocyte telomere length; American Indians; strong heart family study; CARDIOVASCULAR RISK-FACTORS; ABDOMINAL OBESITY; WEIGHT-GAIN; DISEASE; HERITABILITY; INFLAMMATION; METABOLISM; PREVENTION; IMPEDANCE; SMOKING;
D O I：
10.18632/aging.100664
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Shorter leukocyte telomere length (LTL) has been associated with a wide range of age-related disorders including cardiovascular disease (CVD) and diabetes. Obesity is an important risk factor for CVD and diabetes. The association of LTL with obesity is not well understood. This study for the first time examines the association of LTL with obesity indices including body mass index, waist circumference, percent body fat, waist-to-hip ratio, and waist-to-height ratio in 3,256 American Indians (14-93 years old, 60% women) participating in the Strong Heart Family Study. Association of LTL with each adiposity index was examined using multivariate generalized linear mixed model, adjusting for chronological age, sex, study center, education, lifestyle (smoking, alcohol consumption, and total energy intake), high-sensitivity C-reactive protein, hypertension and diabetes. Results show that obese participants had significantly shorter LTL than non-obese individuals (age-adjusted P=0.0002). Multivariate analyses demonstrate that LTL was significantly and inversely associated with all of the studied obesity parameters. Our results may shed light on the potential role of biological aging in pathogenesis of obesity and its comorbidities.
引用
收藏
页码：380 / 389
页数：10
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