Recommend maintenance therapy with lenalidomide in multiple myeloma

被引：3
作者：
Manasanch, Elisabet E. [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77007 USA
来源：
SEMINARS IN ONCOLOGY | 2016年 / 43卷 / 06期
关键词：
Myeloma; Lenalidomide; Maintenance; Transplant; STEM-CELL TRANSPLANTATION; AUTOLOGOUS TRANSPLANTATION; THALIDOMIDE; SURVIVAL;
D O I：
10.1053/j.seminoncol.2016.11.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Thalidomide was the first immunomodulatory drug used as maintenance after autologous stem cell transplant (ASCT) in multiple myeloma (MM). This showed improved progression-free survival (PFS) and in some cases, overall survival (OS). Despite this, use of thalidomide was limited due to toxicity and high rates of therapy discontinuation. Lenalidomide, an analog of thalidomide, had a more favorable toxicity profile making its use in maintenance a potential approach. The use of lenalidomide as a maintenance therapy after ASCT in newly diagnosed MM patients has been investigated in four phase III randomized control studies. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：712 / 713
页数：2
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