Indirect fluorometric determination of diclofenac sodium

被引：19

作者：

Castillo, MA

Bruzzone, L

机构：

[1] Natl Univ La Plata, Fac Ciencias Exactas, Div Quim Analit, RA-1900 La Plata, Argentina

[2] CIDEPINT, RA-1900 La Plata, Argentina

来源：

ANALYTICAL SCIENCES | 2006年 / 22卷 / 03期

关键词：

D O I：

10.2116/analsci.22.431

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and easy method of analysis for diclofenac sodium is reported. A spectrofluorometric method for the microdetermination of diclofenac sodium has been developed through its reaction with cerium(IV) in an acidic solution and measurement of the fluorescence of the Ce(III) ions produced. Under the optimum experimental conditions for the oxidation reaction, 1.0 M H2SO4 with 90 min of heating time (100 degrees C), the range of application is 124.3 - 600 ng mL(-1) and the limit of detection is 72.7 ng mL(-1). The proposed method was applied to the determination of diclofenac sodium in pharmaceutical tablets. The results of the analysis show a good agreement with those obtained by the official USP 27 HPLC method.

引用

收藏

页码：431 / 433

页数：3

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