The effect of rats' diet to production pro-inflammatory and anti-inflammatory cytokines

The aim of this study was to proof supposed influence of long-term consumption of n-3 PUFA on pro-inflammatory and anti-inflammatory cytokine levels in rats' plasma. The results will be used to look for consequences to human nutrition. The plasma of experimental rats was examined for levels of IL-10, IL-6, TNF-alpha, TGF-beta and adiponectin. The sources of PUFA n-3 and n-6 were added to standard feed for rats. The experimental animals were divided into four groups. In the standard feed for the first group 6% of safflower oil was added (n-6). The feed ration of the second group contained 6% of fish oil (n-3, eicosapentaenoic acid - EPA). The last group was fed with addition of 6% Schizochytrium microalgae oil (n-3, dokosahexaenoic acid - DHA). Control group was fed without addition of oils. Addition of oils didn't change homeostasis of cytokine levels of rats' plasma.