Macrophages: The Road Less Traveled, Changing Anticancer Therapy

被引：229

作者：

Guerriero, Jennifer L. ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave, Boston, MA 02215 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2018年 / 24卷 / 05期

基金：

美国国家卫生研究院;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; MONONUCLEAR PHAGOCYTE SYSTEM; TISSUE-RESIDENT MACROPHAGES; BREAST-CANCER METASTASIS; IMMUNOHISTOCHEMICAL LOCALIZATION; ANTITUMOR-ACTIVITY; INFILTRATING MACROPHAGES; ANTIANGIOGENIC THERAPY; DENDRITIC CELLS; MYELOID CELLS;

D O I：

10.1016/j.molmed.2018.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages are present in all vertebrate tissues and have emerged as multifarious cells with complex roles in development, tissue homeostasis, and disease. Macrophages are a major constituent of the tumor microenvironment, where they either promote or inhibit tumorigenesis and metastasis depending on their state. Successful preclinical strategies to target macrophages for anticancer therapy are now being evaluated in the clinic and provide proof of concept that targeting macrophages may enhance current therapies; however, clinical success has been limited. This review discusses the promise of targeting macrophages for anticancer therapy, yet highlights how much is unknown regarding their ontogeny, regulation, and tissue-specific diversity. Further work might identify subsets of macrophages within different tissues, which could reveal novel therapeutic opportunities for anticancer therapy.

引用

页码：472 / 489

页数：18

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