Recombinant Salmonella vaccines for biodefence

被引：19
作者：
Atkins, HS [1 ]
Morton, M
Griffin, KF
Stokes, MGM
Nataro, JP
Titball, RW
机构：
[1] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England
[2] Univ Maryland, Sch Med, Dept Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA
[3] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
来源：
VACCINE | 2006年 / 24卷 / 15期
关键词：
Salmonella vaccine; attenuated Salmonella; biodefence;
D O I：
10.1016/j.vaccine.2005.12.046
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is a requirement for vaccines to protect against pathogens that may be misused for bioterrorism or biowarfare purposes. In particular, biodefence vaccines are required that may be used for safe and easy immunisation of populations and that can rapidly induce mucosal immunity to provide protection at the lung surface against a range of airborne agents. To address this need, recombinant Salmonella vaccines are being developed. In this review, the technologies used, considerations needed, progress made, and future prospects for developing multivalent Salmonella-based vaccines for biodefence are discussed. Crown Copyright (c) 2006 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：2710 / 2717
页数：8
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